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PEN2 Produkte

(Presenilin Enhancer 2 Homolog (PSENEN))
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008].

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Ausgewählte PEN2 Kategorien

PEN2 Antikörper

High quality antibodies with extensive validation data.

PEN2 ELISA Kits

Reliable ELISA kits for a wide range of species.

PEN2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PEN2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse, Rat
Applikation WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN1387540
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7139851
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA
Validierungen
  • (2)
Kat. Nr. ABIN565943
Menge 100 μg
Datenblatt Datenblatt

Empfohlene PEN2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6231793
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Cow
Analytical Method
Validierungen
Kat. Nr. ABIN2870254
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Competition ELISA
Validierungen
Kat. Nr. ABIN6200572
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PEN2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316522
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3107691
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3128357
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PEN2 Produkten

Chu, Peng, Long, Wang, Luo, Sharma, He: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).

Luo, Wang, Li, Kim, Shah, Lee, Thinakaran, Kim, Yu, Xu: "PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 7850-4, (2003) (PubMed).

Crystal, Morais, Pierson, Pijak, Carlin, Lee, Doms: "Membrane topology of gamma-secretase component PEN-2." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 20117-23, (2003) (PubMed).

Takasugi, Tomita, Hayashi, Tsuruoka, Niimura, Takahashi, Thinakaran, Iwatsubo: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).

Marlow, Canet, Haugabook, Hardy, Lahiri, Sambamurti: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).

Francis, McGrath, Zhang, Ruddy, Sym, Apfeld, Nicoll, Maxwell, Hai, Ellis, Parks, Xu, Li, Gurney, Myers, Himes, Hiebsch, Ruble, Nye, Curtis: "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation." in: Developmental cell, Vol. 3, Issue 1, pp. 85-97, (2002) (PubMed).

Synonyme und alternative Namen zu PEN2

presenilin enhancer gamma-secretase subunit (PSENEN), presenilin enhancer 2 (PEN2), presenilin enhancer 2 (Psenen), presenilin enhancer gamma secretase subunit (Psenen), Gamma-secretase subunit pen-2 (pen-2), presenilin enhancer (pen-2), presenilin enhancer gamma secretase subunit S homeolog (psenen.S), presenilin enhancer gamma secretase subunit (psenen), presenilin enhancer gamma-secretase subunit (Psenen), 1700023M09Rik, ACYPI006208, anon-AE003800.1, CG33198, Dmel\\CG33198, dPen-2, MSTP064, PEN-2, Pen-2, pen-2, PEN2, pen2, Psenen, psenen, RGD1312037, zgc:109727

Bezeichner auf Proteinebene für PEN2

  • gamma-secretase subunit PEN-2
  • hematopoietic stem/progenitor cells protein MDS033
  • presenilin enhancer protein 2
  • presenilin enhancer 2
  • LRRGT00140 mRNA
  • liver regeneration-related protein LRRGT00140
  • CG33198-PA
  • pen-2-PA
  • presenilin enhancer 2 homolog
  • presenilin enhancer gamma secretase subunit S homeolog
  • Presenilin enhancer protein 2 homolog
  • presenilin enhancer protein 2 homolog
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