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Presenilin 2 Produkte

(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].

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Ausgewählte Presenilin 2 Kategorien

Presenilin 2 Antikörper

High quality antibodies with extensive validation data.

Presenilin 2 ELISA Kits

Reliable ELISA kits for a wide range of species.

Presenilin 2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Presenilin 2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC (p), IHC (fro)
Validierungen
  • (6)
Kat. Nr. ABIN3032302
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, FACS
Validierungen
  • (4)
  • (2)
Kat. Nr. ABIN1944732
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC, IF
Validierungen
  • (3)
Kat. Nr. ABIN7263725
Menge 200 μL
Datenblatt Datenblatt

Empfohlene Presenilin 2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6969496
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6958724
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rabbit
Analytical Method Quantitative
Validierungen
  • (1)
Kat. Nr. ABIN775490
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Presenilin 2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316520
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Rat
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7411894
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Monkey, Rat
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN2751153
Menge 5 applications
Datenblatt Datenblatt

Neueste Publikationen zu unseren Presenilin 2 Produkten

Hoek, Schlegel, Eichhoff, Widmer, Praetorius, Einarsson, Valgeirsdottir, Bergsteinsdottir, Schepsky, Dummer, Steingrimsson: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).

Kaplan, Renbaum, Vreman, Wong, Levy-Lahad, Hammerman, Stevenson: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).

Ezquerra, Lleó, Castellví, Queralt, Santacruz, Pastor, Molinuevo, Blesa, Oliva: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." in: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).

Di Natale, Perri, Kawarai, Maletta, Tomaino, Sato, Nacmias, Shibata, Sorbi, St George-Hyslop, Bruni, Rogaeva: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." in: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).

Beher, Fricker, Nadin, Clarke, Wrigley, Li, Culvenor, Masters, Harrison, Shearman: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." in: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).

Gamliel, Teicher, Michaelson, Pradier, Hartmann, Beyreuther, Stein: "Increased expression of presenilin 2 inhibits protein synthesis." in: Molecular and cellular neurosciences, Vol. 19, Issue 1, pp. 111-24, (2002) (PubMed).

Sai, Kawamura, Kokame, Yamaguchi, Shiraishi, Suzuki, Suzuki, Kawaichi, Miyata, Kitamura, De Strooper, Yanagisawa, Komano: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Finckh, Müller-Thomsen, Mann, Eggers, Marksteiner, Meins, Binetti, Alberici, Hock, Nitsch, Gal: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." in: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).

Levy-Lahad, Poorkaj, Wang, Fu, Oshima, Mulligan, Schellenberg: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).

Synonyme und alternative Namen zu Presenilin 2

presenilin 2 (PSEN2), presenilin 2 (Psen2), presenilin 2 (psen2), presenilin 2 S homeolog (psen2.S), presenilin 2 (Alzheimer disease 4) (PSEN2), trefoil factor 1 (Tff1), AD3L, ad3l, AD4, ad4, Ad4h, ALG-3, Alg3, CMD1V, pre2, PS-2, PS2, ps2, Ps2, PSEN2, Psnl2, PSNL2, STM2, stm2, zf-PS2

Bezeichner auf Proteinebene für Presenilin 2

  • AD3LP
  • AD5
  • E5-1
  • PS-2
  • STM-2
  • presenilin-2
  • PS-beta
  • presenilin beta
  • presenilin-beta
  • presenilin 2 (Alzheimer disease 4)
  • protein pS2
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