Nicastrin Produkte
(Nicastrin (NCSTN))
Kategorien
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Ausgewählte Nicastrin Kategorien
Nicastrin Antikörper
High quality antibodies with extensive validation data.
Nicastrin ELISA Kits
Reliable ELISA kits for a wide range of species.
Nicastrin Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Nicastrin Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN565059
Menge
50 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (3)
Kat. Nr.
ABIN7268905
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN761801
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Nicastrin ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730247
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN4883865
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1145111
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Nicastrin Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1312150
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1312152
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN7320108
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Nicastrin Produkten
: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).
: "Loss of nicastrin elicits an apoptotic phenotype in mouse embryos." in: Brain research, Vol. 1086, Issue 1, pp. 76-84, (2006) (PubMed).
: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides." in: Trends in cell biology, Vol. 13, Issue 2, pp. 71-8, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 33445-9, (2003) (PubMed).
Synonyme und alternative Namen zu Nicastrin
nicastrin (NCSTN), nicastrin (nct), nicastrin (ncstn), nicastrin (CpipJ_CPIJ001617), nicastrin (Ncstn), Nicastrin (aph-2), 9430068N19Rik, AA727311, agro, APH2, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, Nic, nic, S5A, ST96BBezeichner auf Proteinebene für Nicastrin
- CG7012-PA
- CG7012-PC
- CG7012-PD
- CG7012-PE
- agoraphobic
- dNicastrin
- nct-PA
- nct-PC
- nct-PD
- nct-PE
- nicastrin
- ATAG1874
- anterior pharynx-defective 2
- membrane protein
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