Granulin Produkte
(Granulin (GRN))
Kategorien
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
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Ausgewählte Granulin Kategorien
Granulin Antikörper
High quality antibodies with extensive validation data.
Granulin ELISA Kits
Reliable ELISA kits for a wide range of species.
Granulin Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Granulin Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7440077
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7440863
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ICC, IF, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN2854868
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Granulin ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (6)
Kat. Nr.
ABIN6730966
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Competition ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6967189
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6956290
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Granulin Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN1355792
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123193
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123192
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Granulin Produkten
: "GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium - potential biomarkers in the detection of endometriosis - a pilot study." in: Journal of assisted reproduction and genetics, Vol. 37, Issue 11, pp. 2723-2732, (2020) (PubMed).: "The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status." in: Endokrynologia Polska, Vol. 70, Issue 3, pp. 255-259, (2019) (PubMed).
: "Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 12, pp. E2849-E2858, (2018) (PubMed).
: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations." in: eNeuro, Vol. 4, Issue 4, (2018) (PubMed).
: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness." in: Oncogene, Vol. 34, Issue 14, pp. 1853-64, (2015) (PubMed).
: "The molecular basis for development of proinflammatory autoantibodies to progranulin." in: Journal of autoimmunity, Vol. 61, pp. 17-28, (2015) (PubMed).
: "Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment." in: Journal of neuroinflammation, Vol. 12, pp. 200, (2015) (PubMed).
: "Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population." in: PLoS ONE, Vol. 9, Issue 8, pp. e105583, (2014) (PubMed).
Synonyme und alternative Namen zu Granulin
granulin precursor (GRN), granulin a (grna), Granulins (grn), granulin L homeolog (grn.L), granulin (granulin), granulin (ORF1 granulin), granulin precursor (Grn), granulin (Grn), acrogranin, CLN11, DKFZp459H066, epithelin, GEP, GP88, GRN, grn, MGC53354, PCDGF, PEPI, PGRN, wu:fb11g12, wu:fj18f05Bezeichner auf Proteinebene für Granulin
- granulin
- granulin-a
- zfPGRN-A
- Granulins
- PC cell-derived growth factor
- acrogranin
- granulin-epithelin
- granulins
- proepithelin
- progranulin
- PCDGF
- PEPI
- acrogranulin
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