GREM1 Produkte
(Gremlin 1 (GREM1))
Kategorien
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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Ausgewählte GREM1 Kategorien
GREM1 Antikörper
High quality antibodies with extensive validation data.
GREM1 ELISA Kits
Reliable ELISA kits for a wide range of species.
GREM1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene GREM1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB
Validierungen
- (9)
- (7)
Kat. Nr.
ABIN390078
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (1)
- (5)
Kat. Nr.
ABIN687082
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC, ELISA, IHC (p)
Validierungen
- (3)
- (5)
Kat. Nr.
ABIN545640
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene GREM1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (9)
- (6)
Kat. Nr.
ABIN6730963
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6962271
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6967209
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene GREM1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
- (5)
Kat. Nr.
ABIN6119725
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN4949105
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123202
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren GREM1 Produkten
: "Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells." in: Journal of diabetes research, Vol. 2020, pp. 9238742, (2021) (PubMed).: "Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis." in: Scientific reports, Vol. 9, Issue 1, pp. 6867, (2020) (PubMed).
: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).
: "Platelets as a novel source of Gremlin-1: Implications for thromboinflammation." in: Thrombosis and haemostasis, Vol. 117, Issue 2, pp. 311-324, (2018) (PubMed).
: "The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells." in: European cells & materials, Vol. 33, pp. 197-210, (2017) (PubMed).
: "Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. ..." in: Scientific reports, Vol. 7, pp. 44941, (2017) (PubMed).
: "Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells." in: Molecular medicine reports, Vol. 15, Issue 4, pp. 2186-2194, (2017) (PubMed).
: "Overexpression of Gremlin promotes non-small cell lung cancer progression." in: Tumour biology, Vol. 37, Issue 2, pp. 2597-602, (2016) (PubMed).
: "GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness." in: The Journal of rheumatology, Vol. 43, Issue 3, pp. 474-85, (2016) (PubMed).
: "Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension." in: American journal of respiratory cell and molecular biology, Vol. 55, Issue 4, pp. 564-575, (2016) (PubMed).
Synonyme und alternative Namen zu GREM1
gremlin 1a, DAN family BMP antagonist (grem1a), gremlin 1, DAN family BMP antagonist (GREM1), gremlin 1 (LOC662541), gremlin 1, DAN family BMP antagonist (grem1), gremlin 1, DAN family BMP antagonist (Grem1), gremlin 1, DAN family BMP antagonist L homeolog (grem1.L), Cktsf1b1, CKTSF1B1, cktsf1b1, dand2, DAND2, drm, Drm, DRM, Grem, grem1, GREM1, gremlin, GREMLIN, gremlin-1, ihg-2, IHG-2, ld, MGC136702, pig2, zgc:136702Bezeichner auf Proteinebene für GREM1
- gremlin 1 homolog a, cysteine knot superfamily
- gremlin 1 homolog, cysteine knot superfamily
- gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
- gremlin 1
- GLEAN_07044
- cysteine knot superfamily 1
- cysteine knot superfamily 1, BMP antagonist 1
- down-regulated in Mos-transformed cells protein
- down-regulated in v-mos-transformed cells
- gremlin-1
- gremlin 1, cysteine knot superfamily, homolog
- Cysteine knot superfamily 1, BMP antagonist 1
- DAN domain family member 2
- cell proliferation-inducing gene 2 protein
- gremlin 1-like protein
- increased in high glucose-2
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