Gremlin 1 (GREM1) (AA 147-175), (C-Term) Antikörper

Details zu Produkt Nr. ABIN390078, Anbieter: Anmelden zum Anzeigen
Antigen
  • grem1
  • MGC136702
  • zgc:136702
  • GREM1
  • drm
  • pig2
  • dand2
  • ihg-2
  • gremlin
  • Cktsf1b1
  • Drm
  • Grem
  • ld
  • gremlin-1
  • CKTSF1B1
  • DAND2
  • DRM
  • GREMLIN
  • IHG-2
  • cktsf1b1
  • gremlin 1a, DAN family BMP antagonist
  • gremlin 1, DAN family BMP antagonist
  • gremlin 1
  • gremlin 1, DAN family BMP antagonist L homeolog
  • grem1a
  • GREM1
  • LOC662541
  • grem1
  • Grem1
  • grem1.L
Epitop
AA 147-175, C-Term
27
17
15
15
11
8
8
7
6
5
4
3
3
2
1
1
1
1
1
1
Reaktivität
Human, Maus
110
63
29
8
6
4
4
3
3
2
2
2
2
2
Wirt
Kaninchen
119
15
13
Klonalität (Klon)
Polyklonal ()
Konjugat
Unkonjugiert
16
11
7
4
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
105
72
49
14
13
12
8
6
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 AA from the C-terminal region of human GREMLIN.
Klon RB2060
Isotyp Ig Fraction
Homologie Rat (Rattus)
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Andere Bezeichnung GREMLIN (GREM1 Antibody Abstract)
Hintergrund Function
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.

Cellular Location
Secreted (Probable).

Tissue Location
Highly expressed in spleen and to a lesser extent in lung, skeletal muscle and kidney. Expressed only in non- transformed cells or primary fibroblasts in culture but not in established transformed or tumor derived cell lines. Broadly expressed in limb bud mesenchyme but restricted to the distal limb bud mesenchyme and concentrated posteriorly. Expressed in ovary especially in granulosa cells of follicles of type 4

Synonyms: Cysteine KNOT superfamily 1, BMP antagonist 1
Molekulargewicht 20697 Da
Gen-ID 23892
UniProt O70326
Pathways Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
Applikations-hinweise Suggested dilutions:
WB = 1:1000, IHC (p) = 1:50-100
Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung Avoid freeze-thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibody (ABIN390078) Western blot analysis of anti-Gremlin Pab (ABIN390078) in CEM cell line lysates (35 µ...
Western Blotting (WB) image for anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibody (ABIN390078) Western blot analysis of anti-Gremlin Pab (ABIN390078) in mouse liver cell lysate. Gr...
Immunohistochemistry (IHC) image for anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibody (ABIN390078) Formalin-PBS and Bouin embedded paraffin human renal tissue pretreated with heat indu...
Western Blotting (WB) image for anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibody (ABIN390078) Anti-GREMLIN Antibody (C-term) at 1:2000 dilution + Mouse skeletal muscle lysate Lysa...
Produkt verwendet in: Staloch, Gao, Liu, Xu, Feng, Aronson, Falzon, Greeley, Rastellini, Chao, Hellmich, Cao, Ko: "Gremlin is a key pro-fibrogenic factor in chronic pancreatitis." in: Journal of molecular medicine (Berlin, Germany), 2015 (PubMed).

Droguett, Krall, Burgos, Valderrama, Carpio, Ardiles, Rodriguez-Diez, Kerr, Walz, Ruiz-Ortega, Egido, Mezzano: "Tubular overexpression of gremlin induces renal damage susceptibility in mice." in: PLoS ONE, Vol. 9, Issue 7, pp. e101879, 2014 (PubMed).

Ahn, Mercado, Laé, Ladanyi: "Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma." in: Oncology reports, Vol. 30, Issue 2, pp. 968-78, 2013 (PubMed).

Gelse, Ekici, Cipa, Swoboda, Carl, Olk, Hennig, Klinger: "Molecular differentiation between osteophytic and articular cartilage--clues for a transient and permanent chondrocyte phenotype." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 20, Issue 2, pp. 162-71, 2012 (PubMed).

Jara, Chacón, Burgos, Droguett, Valdivieso, Ortiz, Troncoso, Mezzano: "Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 4, pp. 1121-9, 2009 (PubMed).

Carvajal, Droguett, Burgos, Aros, Ardiles, Flores, Carpio, Ruiz-Ortega, Egido, Mezzano: "Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy." in: Transplantation proceedings, Vol. 40, Issue 3, pp. 734-9, 2008 (PubMed).

Mezzano, Droguett, Burgos, Aros, Ardiles, Flores, Carpio, Carvajal, Ruiz-Ortega, Egido: "Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 22, Issue 7, pp. 1882-90, 2007 (PubMed).

Wordinger, Fleenor, Hellberg, Pang, Tovar, Zode, Fuller, Clark: "Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma." in: Investigative ophthalmology & visual science, Vol. 48, Issue 3, pp. 1191-200, 2007 (PubMed).

Frank, Kho, Schatton, Murphy, Molloy, Zhan, Ramoni, Frank, Kohane, Gussoni: "Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin." in: The Journal of cell biology, Vol. 175, Issue 1, pp. 99-110, 2006 (PubMed).

Allgemeine Veröffentlichungen Cooney, Baker, Brain, Danis, Pichulik, Allan, Ferguson, Campbell, Jewell, Simmons: "NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation." in: Nature medicine, Vol. 16, Issue 1, pp. 90-7, 2010 (PubMed).

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