BIN1 Produkte
(Bridging Integrator 1 (BIN1))
Kategorien
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011].
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Ausgewählte BIN1 Kategorien
BIN1 Antikörper
High quality antibodies with extensive validation data.
BIN1 ELISA Kits
Reliable ELISA kits for a wide range of species.
BIN1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene BIN1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7259755
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC, ICC, FACS
Validierungen
- (5)
Kat. Nr.
ABIN5542281
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, ICC, IHC (p)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN2855595
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene BIN1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6954195
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6201968
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6201967
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene BIN1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN2715270
Menge
20 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN667182
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346679
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren BIN1 Produkten
: "Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment." in: Molecular medicine (Cambridge, Mass.), Vol. 25, Issue 1, pp. 53, (2020) (PubMed).: "FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis." in: Nature cell biology, Vol. 20, Issue 9, pp. 1023-1031, (2019) (PubMed).
: "Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain." in: Acta neuropathologica communications, Vol. 3, pp. 58, (2015) (PubMed).
: "Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology." in: Journal of Alzheimer's disease : JAD, Vol. 42, Issue 4, pp. 1221-7, (2014) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy." in: Nature genetics, Vol. 39, Issue 9, pp. 1134-9, (2007) (PubMed).
: "Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival." in: Cancer biology & therapy, Vol. 6, Issue 2, pp. 192-4, (2007) (PubMed).
: "Human T-cell lymphotrophic virus type I rex and p30 interactions govern the switch between virus latency and replication." in: The Journal of biological chemistry, Vol. 282, Issue 19, pp. 14608-15, (2007) (PubMed).
: "A role for the putative tumor suppressor Bin1 in muscle cell differentiation." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 566-75, (1998) (PubMed).
: "Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing." in: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31453-8, (1998) (PubMed).
Synonyme und alternative Namen zu BIN1
bridging integrator 1 (BIN1), bridging integrator 1 S homeolog (bin1.S), bridging integrator 1 (bin1), bridging integrator 1b (bin1b), bridging integrator 1 (Bin1), ALP-1, amph2, AMPH2, amphl, AMPHL, Amphl, bin1, BIN1, BRAMP-2, cb57, MGC53185, MGC76187, sh3p9, SH3P9, zgc:86701Bezeichner auf Proteinebene für BIN1
- bridging integrator 1
- myc box-dependent-interacting protein 1-like
- amphiphysin II
- amphiphysin-like protein
- box dependant MYC interacting protein 1
- box-dependent myc-interacting protein 1
- myc box-dependent-interacting protein 1
- SH3 domain-containing protein 9
- amphiphysin 2
- myc box dependent interacting protein 1
- Amph2
- amphiphysin IIamph2
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