STAT3 Antikörper
-
- Target Alle STAT3 Antikörper anzeigen
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
-
Reaktivität
- Human, Maus, Affe
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser STAT3 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human STAT3 expressed in E. coli.
- Klon
- 3B5
- Isotyp
- IgG1
- Top Product
- Discover our top product STAT3 Primärantikörper
-
-
- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
-
-
Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3." in: Journal of molecular graphics & modelling, Vol. 28, Issue 4, pp. 347-56, (2009) (PubMed).
: "
-
Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3." in: Journal of molecular graphics & modelling, Vol. 28, Issue 4, pp. 347-56, (2009) (PubMed).
-
- Target
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
- Andere Bezeichnung
- STAT3 (STAT3 Produkte)
- Synonyme
- 1110034C02Rik antikoerper, AW109958 antikoerper, Aprf antikoerper, APRF antikoerper, HIES antikoerper, Xstat3 antikoerper, aprf antikoerper, hies antikoerper, stat3 antikoerper, wu:fc15d02 antikoerper, wu:fl59g06 antikoerper, z-Stat3 antikoerper, signal transducer and activator of transcription 3 antikoerper, signal transduction and activation of transcription 3 antikoerper, signal transducer and activator of transcription 3, gene 1 L homeolog antikoerper, signal transducer and activator of transcription 3 (acute-phase response factor) antikoerper, STAT3 antikoerper, stat3 antikoerper, Stat3 antikoerper, stat3.1.L antikoerper
- Hintergrund
-
Description: The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Aliases: APRF, HIES, FLJ20882, MGC16063, STAT3
- Molekulargewicht
- 88 kDa
- Gen-ID
- 6774
- HGNC
- 6774
- Pathways
- JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
-