STAT3 Antikörper
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- Target Alle STAT3 Antikörper anzeigen
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser STAT3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of STAT3 expressed in E. coli.
- Klon
- 7G3H4
- Isotyp
- IgG1
- Top Product
- Discover our top product STAT3 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 115, Issue 12, pp. 1331-43, (2008) (PubMed).
: "Significance of p-STAT3 expression in human colorectal adenocarcinoma." in: Oncology reports, Vol. 20, Issue 3, pp. 597-604, (2008) (PubMed).
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Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 115, Issue 12, pp. 1331-43, (2008) (PubMed).
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- Target
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
- Andere Bezeichnung
- STAT3 (STAT3 Produkte)
- Synonyme
- 1110034C02Rik antikoerper, AW109958 antikoerper, Aprf antikoerper, APRF antikoerper, HIES antikoerper, Xstat3 antikoerper, aprf antikoerper, hies antikoerper, stat3 antikoerper, wu:fc15d02 antikoerper, wu:fl59g06 antikoerper, z-Stat3 antikoerper, signal transducer and activator of transcription 3 antikoerper, signal transduction and activation of transcription 3 antikoerper, signal transducer and activator of transcription 3, gene 1 L homeolog antikoerper, signal transducer and activator of transcription 3 (acute-phase response factor) antikoerper, STAT3 antikoerper, stat3 antikoerper, Stat3 antikoerper, stat3.1.L antikoerper
- Hintergrund
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Description: STAT3: signal transducer and activator of transcription 3 (acute-phase response factor). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Aliases: APRF, HIES
- Gen-ID
- 6774
- HGNC
- 6774
- Pathways
- JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
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