AKT3 Antikörper

Produktnummer ABIN965532

Produktdetails anti-AKT3 Antikörper

Target: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser AKT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Ni-NTA purified truncated recombinant Akt3 expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Crude ascites.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Referenzen für anti-AKT3 Antikörper (ABIN965532)

Easton, Cho, Roovers, Shineman, Mizrahi, Forman, Lee, Szabolcs, de Jong, Oltersdorf, Ludwig, Efstratiadis, Birnbaum: "Role for Akt3/protein kinase Bgamma in attainment of normal brain size." in: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1869-78, (2005) (PubMed).

Stahl, Sharma, Cheung, Zimmerman, Cheng, Bosenberg, Kester, Sandirasegarane, Robertson: "Deregulated Akt3 activity promotes development of malignant melanoma." in: Cancer research, Vol. 64, Issue 19, pp. 7002-10, (2004) (PubMed).

Details zu AKT3

Target: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Andere Bezeichnung: Akt3 (AKT3 Produkte)

Synonyme: MPPH antikoerper, PKB-GAMMA antikoerper, PKBG antikoerper, PRKBG antikoerper, RAC-PK-gamma antikoerper, RAC-gamma antikoerper, STK-2 antikoerper, AI851531 antikoerper, D930002M15Rik antikoerper, Nmf350 antikoerper, Pkbg antikoerper, AKT serine/threonine kinase 3 antikoerper, thymoma viral proto-oncogene 3 antikoerper, v-akt murine thymoma viral oncogene homolog 3b antikoerper, AKT3 antikoerper, Akt3 antikoerper, akt3b antikoerper

Hintergrund: Akt3 (also designated protein kinase B gamma or vakt murine thymoma viral oncogene homolog 3),with 479-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt2. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake.Akt3 is not required for the maintenance of normal carbohydrate metabolism but is essential for the attainment of normal organ size. Identifying Akt3 as a selective target in melanoma cells also provides new therapeutic opportunities for patients in the advanced stages of this disease.

Gen-ID: 10000

Pathways: PI3K-Akt Signalweg, RTK Signalweg, TLR Signalweg, Hepatitis C, VEGF Signaling