AKT2 Antikörper (C-Term)

Produktnummer ABIN950330

Produktdetails anti-AKT2 Antikörper

Target: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser AKT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-RYDSLGLLEL DQRT

Spezifität: This antibody recognizes AKT2 (C-term).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Dog.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_001617.1. Genename: AKT2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu AKT2

Target: AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))

Andere Bezeichnung: AKT2 / PKB beta (AKT2 Produkte)

Synonyme: AKT2 antikoerper, pkbb antikoerper, pkbbeta antikoerper, pkbss antikoerper, prkbb antikoerper, rac-beta antikoerper, v-akt2 antikoerper, 2410016A19Rik antikoerper, AW554154 antikoerper, PKB antikoerper, PKBbeta antikoerper, HIHGHH antikoerper, PKBB antikoerper, PKBBETA antikoerper, PRKBB antikoerper, RAC-BETA antikoerper, cb945 antikoerper, akt2-a antikoerper, AKT serine/threonine kinase 2 antikoerper, v-akt murine thymoma viral oncogene homolog 2 antikoerper, thymoma viral proto-oncogene 2 antikoerper, v-akt murine thymoma viral oncogene homolog 2 L homeolog antikoerper, AKT2 antikoerper, akt2 antikoerper, Akt2 antikoerper, akt2.L antikoerper

Hintergrund: Akt, protein kinase B (PKB), is a serine/threonine kinase, which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers. AKT2 encodes a RAC/AKT-type protein kinase that contains a N-terminal pleckstrin-homology (PH) domain and a central catalytic domain closely related to both cAMP-dependent protein kinase and protein kinase C. The protein is a member of PI3K-mediated signalling pathways associated with the regulation of proliferation, survival, protein synthesis, and metabolism. It is activated by a variety of growth factors. AKT2 has been shown to be transcriptionally regulated by MyoD and to activate MyoD-myocyte enhancer binding factor-2 (MEF2) transactivation activity during muscle differentiation. Glycogen synthase kinase 3 (GSK-3) also has been shown to be a downstream target of AKT2. The AKT2 gene is one of the human homologues of v-akt, the transduced oncogene of the AKT8 virus, which induces lymphomas in mice. It has been implicated in breast, ovarian, and pancreatic cancers.Synonyms: Protein kinase Akt-2, Protein kinase B beta, RAC-PK-beta, RAC-beta serine/threonine-protein kinase

Gen-ID: 208

NCBI Accession: NP_001617

Pathways: PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, TLR Signalweg, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling