FOXO1 Antikörper (AA 201-300) (Cy7)
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- Target Alle FOXO1 Antikörper anzeigen
- FOXO1 (Forkhead Box O1 (FOXO1))
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Bindungsspezifität
- AA 201-300
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FOXO1 Antikörper ist konjugiert mit Cy7
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Applikation
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Kreuzreaktivität
- Human, Maus
- Homologie
- Rat,Dog,Sheep,Pig,Horse,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FOXO1 + FOXO3 + FOXO4
- Isotyp
- IgG
- Top Product
- Discover our top product FOXO1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- FOXO1 (Forkhead Box O1 (FOXO1))
- Andere Bezeichnung
- FOXO1/3/4 (FOXO1 Produkte)
- Synonyme
- FKH1 antikoerper, FKHR antikoerper, FOXO1A antikoerper, FoxO1a.1 antikoerper, foxo1 antikoerper, zgc:153388 antikoerper, Fkhr antikoerper, Foxo1a antikoerper, AI876417 antikoerper, Afxh antikoerper, Fkhr1 antikoerper, fkh1 antikoerper, fkhr antikoerper, foxo1a antikoerper, xFoxO1 antikoerper, FoxO1A antikoerper, foxo1a.2 antikoerper, forkhead box O1 antikoerper, forkhead box O1 a antikoerper, forkhead box O1 L homeolog antikoerper, forkhead box O1 b antikoerper, FOXO1 antikoerper, foxo1a antikoerper, Foxo1 antikoerper, foxo1 antikoerper, foxo1.L antikoerper, foxo1b antikoerper
- Hintergrund
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Synonyms: AFX1, FOXO1+FOXO3+FOXO4, FKH1, FKHRL1, FKHRL1P2, Forkhead box O1, Forkhead box O3, Forkhead box O4, FOXO1, FOXO2, FOXO3, FOXO4, MLLT7, FOXO1_HUMAN.
Background: FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
- Gen-ID
- 2308
- Pathways
- PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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