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FOXO1 Antikörper (pSer256)

FOXO1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6255137
  • Target Alle FOXO1 Antikörper anzeigen
    FOXO1 (Forkhead Box O1 (FOXO1))
    Bindungsspezifität
    • 24
    • 21
    • 18
    • 18
    • 17
    • 16
    • 16
    • 16
    • 11
    • 10
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer256
    Reaktivität
    • 230
    • 161
    • 150
    • 48
    • 30
    • 25
    • 18
    • 11
    • 9
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 211
    • 21
    • 1
    • 1
    Kaninchen
    Klonalität
    • 204
    • 30
    Polyklonal
    Konjugat
    • 104
    • 11
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FOXO1 Antikörper ist unkonjugiert
    Applikation
    • 197
    • 91
    • 78
    • 65
    • 57
    • 56
    • 44
    • 32
    • 20
    • 19
    • 8
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Phospho-FOXO1A (Ser256) Antibody detects endogenous levels of FOXO1A only when phosphorylated at Serine 256.
    Homologie
    Pig,Bovine,Dog,Chicken,Xenopus
    Aufreinigung
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human FOXO1A around the phosphorylation site of Ser256.
    Isotyp
    IgG
    Top Product
    Discover our top product FOXO1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    FOXO1 (Forkhead Box O1 (FOXO1))
    Andere Bezeichnung
    FOXO1 (FOXO1 Produkte)
    Synonyme
    FKH1 antikoerper, FKHR antikoerper, FOXO1A antikoerper, FoxO1a.1 antikoerper, foxo1 antikoerper, zgc:153388 antikoerper, Fkhr antikoerper, Foxo1a antikoerper, AI876417 antikoerper, Afxh antikoerper, Fkhr1 antikoerper, fkh1 antikoerper, fkhr antikoerper, foxo1a antikoerper, xFoxO1 antikoerper, FoxO1A antikoerper, foxo1a.2 antikoerper, forkhead box O1 antikoerper, forkhead box O1 a antikoerper, forkhead box O1 L homeolog antikoerper, forkhead box O1 b antikoerper, FOXO1 antikoerper, foxo1a antikoerper, Foxo1 antikoerper, foxo1 antikoerper, foxo1.L antikoerper, foxo1b antikoerper
    Hintergrund

    Description: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).

    Gene: FOXO1

    Molekulargewicht
    69kDa
    Gen-ID
    2308
    UniProt
    Q12778
    Pathways
    PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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