ULK1 Antikörper (AA 951-1050) (Alexa Fluor 488)

Produktnummer ABIN883967

Produktdetails anti-ULK1 Antikörper (Alexa Fluor 488)

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Bindungsspezifität: AA 951-1050

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULK1 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ATG1/ULK1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ULK1

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Andere Bezeichnung: ATG1/ULK1 (ULK1 Produkte)

Synonyme: ATG1 antikoerper, ATG1A antikoerper, UNC51 antikoerper, Unc51.1 antikoerper, hATG1 antikoerper, si:dkey-11o18.7 antikoerper, ulk1 antikoerper, ULK1 antikoerper, AU041434 antikoerper, mKIAA0722 antikoerper, zgc:195008 antikoerper, unc-51 like autophagy activating kinase 1 antikoerper, unc-51 like kinase 1 antikoerper, unc-51 like autophagy activating kinase 1a antikoerper, ULK1 antikoerper, Ulk1 antikoerper, ulk1b antikoerper, ulk1a antikoerper

Hintergrund:

Synonyms: ATG1, ATG1A, UNC51, hATG1, Unc51.1, Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, Unc-51-like kinase 1, ULK1, KIAA722

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

Gen-ID: 8408

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagie