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ULK1 Antikörper (AA 951-1050)

ULK1 Reaktivität: Human, Maus, Ratte ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN701440
  • Target Alle ULK1 Antikörper anzeigen
    ULK1 (Unc-51 Like Kinase 1 (ULK1))
    Bindungsspezifität
    • 25
    • 16
    • 15
    • 14
    • 13
    • 11
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 951-1050
    Reaktivität
    • 193
    • 76
    • 65
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 196
    • 3
    • 2
    Kaninchen
    Klonalität
    • 189
    • 12
    Polyklonal
    Konjugat
    • 54
    • 23
    • 19
    • 18
    • 13
    • 11
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ULK1 Antikörper ist unkonjugiert
    Applikation
    • 111
    • 94
    • 29
    • 25
    • 25
    • 25
    • 20
    • 12
    • 9
    • 9
    • 5
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ATG1/ULK1
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Shen, Hou, Zhu, Zhao, Ouyang, Feng et al.: "Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion ..." in: Journal of neurochemistry, Vol. 140, Issue 5, pp. 799-813, (2016) (PubMed).

    Gao, Wang, Yi, Kou, Xie, Song: "Activation of lysosomal degradative pathway in spinal cord tissues of carbon disulfide-treated rats." in: Chemico-biological interactions, Vol. 219C, pp. 76-82, (2014) (PubMed).

    Song, Kou, Zou, Gao, Zeng, Xie: "Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens." in: Neurochemistry international, Vol. 64, pp. 1-8, (2013) (PubMed).

  • Target
    ULK1 (Unc-51 Like Kinase 1 (ULK1))
    Andere Bezeichnung
    ATG1/ULK1 (ULK1 Produkte)
    Synonyme
    ATG1 antikoerper, ATG1A antikoerper, UNC51 antikoerper, Unc51.1 antikoerper, hATG1 antikoerper, si:dkey-11o18.7 antikoerper, ulk1 antikoerper, ULK1 antikoerper, AU041434 antikoerper, mKIAA0722 antikoerper, zgc:195008 antikoerper, unc-51 like autophagy activating kinase 1 antikoerper, unc-51 like kinase 1 antikoerper, unc-51 like autophagy activating kinase 1a antikoerper, ULK1 antikoerper, Ulk1 antikoerper, ulk1b antikoerper, ulk1a antikoerper
    Hintergrund

    Synonyms: ATG1, ATG1A, UNC51, hATG1, Unc51.1, Serine/threonine-protein kinase ULK1, Autophagy-related protein 1 homolog, Unc-51-like kinase 1, ULK1, KIAA722

    Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

    Gen-ID
    8408
    UniProt
    O75385
    Pathways
    Regulation of Cell Size, Autophagie
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