FLT4 Antikörper (AA 901-1000) (Cy5.5)
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- Target Alle FLT4 Antikörper anzeigen
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
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Bindungsspezifität
- AA 901-1000
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FLT4 Antikörper ist konjugiert mit Cy5.5
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from mouse VEGFR3
- Isotyp
- IgG
- Top Product
- Discover our top product FLT4 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
- Andere Bezeichnung
- VEGFR3 (FLT4 Produkte)
- Synonyme
- FLT41 antikoerper, LMPH1A antikoerper, PCL antikoerper, VEGFR3 antikoerper, AI323512 antikoerper, Chy antikoerper, Flt-4 antikoerper, VEGFR-3 antikoerper, Vegfr3 antikoerper, cb1059 antikoerper, fms related tyrosine kinase 4 antikoerper, FMS-like tyrosine kinase 4 antikoerper, fms-related tyrosine kinase 4 antikoerper, FLT4 antikoerper, Flt4 antikoerper, flt4 antikoerper
- Hintergrund
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Synonyms: Chy, Flt-4, VEGFR3, VEGFR-3, AI323512, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, Flt4
Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
- Gen-ID
- 14257
- UniProt
- P35917
- Pathways
- RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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