PIK3CA Antikörper (Catalytic Subunit alpha)

Produktnummer ABIN7163188

Produktdetails anti-PIK3CA Antikörper

Target: PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))

Bindungsspezifität: AA 1-206, Catalytic Subunit alpha

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3CA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein (1-206AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIK3CA

Target: PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))

Andere Bezeichnung: PIK3CA (PIK3CA Produkte)

Synonyme: CLOVE antikoerper, CWS5 antikoerper, MCAP antikoerper, MCM antikoerper, MCMTC antikoerper, PI3K antikoerper, p110-alpha antikoerper, C-P3K antikoerper, PI3-kinase antikoerper, PI3K-alpha antikoerper, pi3-k antikoerper, pi3k antikoerper, AA414921 antikoerper, C530050K14 antikoerper, p50alpha antikoerper, p55alpha antikoerper, p85alpha antikoerper, 6330412C24Rik antikoerper, caPI3K antikoerper, p110 antikoerper, p110alpha antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha antikoerper, Phosphoinositide-3-kinase, catalytic, alpha polypeptide antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha antikoerper, phosphoinositide-3-kinase regulatory subunit 1 antikoerper, PIK3CA antikoerper, GL50803_14855 antikoerper, pik3ca antikoerper, Pik3ca antikoerper, Pik3r1 antikoerper

Hintergrund:

Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).

Aliases: 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody, 5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody, caPI3K antibody, CLOVE antibody, CWS5 antibody, MCAP antibody, MCM antibody, MCMTC antibody, MGC142161 antibody, MGC142163 antibody, p110 alpha antibody, p110alpha antibody, Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody, Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody, Phosphatidylinositol-4 antibody, Phosphoinositide 3 kinase catalytic alpha polypeptide antibody, PI 3 Kinase catalytic subunit alpha antibody, PI3 kinase p110 subunit alpha antibody, PI3-kinase subunit alpha antibody, PI3K antibody, PI3K-alpha antibody, PI3KC A antibody, PIK3C A antibody, Pik3ca antibody, PK3CA antibody, PK3CA_HUMAN antibody, PtdIns 3 kinase p110 antibody, PtdIns-3-kinase subunit alpha antibody, PtdIns-3-kinase subunit p110-alpha antibody, Serine/threonine protein kinase PIK3CA antibody

UniProt: P42336

Pathways: PI3K-Akt Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, AMPK Signaling, Interferon-gamma Pathway, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling