PSMD14 Antikörper (Regulatory Subunit 14)

Produktnummer ABIN7139700

Produktdetails anti-PSMD14 Antikörper

Target: PSMD14 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 (PSMD14))

Bindungsspezifität: AA 264-283, Regulatory Subunit 14

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMD14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Antigen Affinity Purified

Immunogen: Peptide sequence from Human 26S proteasome non-ATPase regulatory subunit 14 protein (264-283AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PSMD14

Target: PSMD14 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 14 (PSMD14))

Andere Bezeichnung: PSMD14 (PSMD14 Produkte)

Synonyme: PAD1 antikoerper, POH1 antikoerper, RPN11 antikoerper, 2610312C03Rik antikoerper, 3200001M20Rik antikoerper, AA986732 antikoerper, Pad1 antikoerper, Poh1 antikoerper, rpm11 antikoerper, zgc:162272 antikoerper, proteasome 26S subunit, non-ATPase 14 antikoerper, proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 antikoerper, 26S proteasome non-ATPase regulatory subunit 14 antikoerper, proteasome 26S subunit, non-ATPase 14 L homeolog antikoerper, 26S proteasome-associated pad1 homolog antikoerper, PSMD14 antikoerper, Psmd14 antikoerper, rpn-11 antikoerper, psmd14 antikoerper, psmd14.L antikoerper

Hintergrund:

Background: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving \\\'Lys-63\\\'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.

Aliases: 26S proteasome non-ATPase regulatory subunit 14 antibody, 26S proteasome regulatory subunit rpn11 antibody, 26S proteasome-associated PAD1 homolog 1 antibody, 26S proteasome-associated PAD1 homolog antibody, PAD1 antibody, PAD1, yeast, homolog of antibody, POH1 antibody, Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 antibody, Proteasome 26S subunit non ATPase 14 antibody, PSDE_HUMAN antibody, Psmd14 antibody, RPN11 antibody, Testis tissue sperm binding protein Li 69n antibody

UniProt: O00487

Pathways: Mitotic G1-G1/S Phases, DNA Replication, M Phase, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Ubiquitin Proteasome Pathway