LATS1 Antikörper

Produktnummer ABIN7115777

Produktdetails anti-LATS1 Antikörper

Target: LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LATS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: LATS, large tumor suppressor, homolog 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu LATS1

Target: LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Andere Bezeichnung: LATS1 (LATS1 Produkte)

Synonyme: WARTS antikoerper, wts antikoerper, AW208599 antikoerper, Lats antikoerper, si:dkey-181i3.5 antikoerper, wu:fc19a11 antikoerper, zgc:123219 antikoerper, lats1 antikoerper, RGD1564085 antikoerper, warts antikoerper, large tumor suppressor kinase 1 antikoerper, large tumor suppressor antikoerper, large tumor suppressor kinase 1 S homeolog antikoerper, LATS1 antikoerper, Lats1 antikoerper, lats1 antikoerper, lats1.S antikoerper

Hintergrund: Synonyms:LATS1, WARTS, WARTS protein kinase, wts Background:Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

Molekulargewicht: 140 kDa

Gen-ID: 9113

UniProt: O95835

Pathways: Regulation of Actin Filament Polymerization, Maintenance of Protein Location