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LATS1 Antikörper (N-Term)

LATS1 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal RB3029 unconjugated
Produktnummer ABIN391033
  • Target Alle LATS1 Antikörper anzeigen
    LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
    Bindungsspezifität
    • 16
    • 13
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reaktivität
    • 61
    • 47
    • 13
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 59
    • 2
    Kaninchen
    Klonalität
    • 60
    • 1
    Polyklonal
    Konjugat
    • 19
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LATS1 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 24
    • 16
    • 13
    • 13
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
    Klon
    RB3029
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product LATS1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

  • Target
    LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
    Andere Bezeichnung
    LATS1 (LATS1 Produkte)
    Synonyme
    WARTS antikoerper, wts antikoerper, AW208599 antikoerper, Lats antikoerper, si:dkey-181i3.5 antikoerper, wu:fc19a11 antikoerper, zgc:123219 antikoerper, lats1 antikoerper, RGD1564085 antikoerper, warts antikoerper, large tumor suppressor kinase 1 antikoerper, large tumor suppressor antikoerper, large tumor suppressor kinase 1 S homeolog antikoerper, LATS1 antikoerper, Lats1 antikoerper, lats1 antikoerper, lats1.S antikoerper
    Hintergrund
    The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
    Molekulargewicht
    126870
    Gen-ID
    9113
    NCBI Accession
    NP_001257448, NP_004681
    UniProt
    O95835
    Pathways
    Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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