LATS1 Antikörper (AA 1-30)

Produktnummer ABIN3031593

Produktdetails anti-LATS1 Antikörper

Target: LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Bindungsspezifität: AA 1-30

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LATS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this LATS1 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the LATS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the LATS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu LATS1

Target: LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Andere Bezeichnung: LATS1 (LATS1 Produkte)

Synonyme: WARTS antikoerper, wts antikoerper, AW208599 antikoerper, Lats antikoerper, si:dkey-181i3.5 antikoerper, wu:fc19a11 antikoerper, zgc:123219 antikoerper, lats1 antikoerper, RGD1564085 antikoerper, warts antikoerper, large tumor suppressor kinase 1 antikoerper, large tumor suppressor antikoerper, large tumor suppressor kinase 1 S homeolog antikoerper, LATS1 antikoerper, Lats1 antikoerper, lats1 antikoerper, lats1.S antikoerper

Hintergrund: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

UniProt: O95835

Pathways: Regulation of Actin Filament Polymerization, Maintenance of Protein Location