Cyclin A1 Antikörper

Produktnummer ABIN7261576

Produktdetails anti-Cyclin A1 Antikörper

Target: Cyclin A1 (CCNA1)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human CCNA1 (NP_001104515.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Cyclin A1

Target: Cyclin A1 (CCNA1)

Andere Bezeichnung: CCNA1 (CCNA1 Produkte)

Synonyme: fd14f08 antikoerper, wu:fd14f08 antikoerper, wu:fi20d12 antikoerper, zgc:111869 antikoerper, MGC81965 antikoerper, cyclin-A1 antikoerper, CCNA1 antikoerper, MGC132235 antikoerper, cyclin-A1-2 antikoerper, Cyclin-A1 antikoerper, ccna1 antikoerper, cyclin A1 antikoerper, cyclin A1 L homeolog antikoerper, CYCLIN A1;2 antikoerper, cyclin A1 S homeolog antikoerper, CCNA1 antikoerper, ccna1 antikoerper, ccna1.L antikoerper, CYCA1;2 antikoerper, Ccna1 antikoerper, ccna1.S antikoerper

Hintergrund: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 52 kDa

Calculated_MW: 47 kDa/52 kDa

Gen-ID: 8900

UniProt: P78396

Pathways: Apoptose, Zellzyklus, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA