IKKi/IKKe Antikörper (C-Term)

Produktnummer ABIN6990163

Produktdetails anti-IKKi/IKKe Antikörper

Target: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKKi/IKKe Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: It has no cross response to IKKa, IKKb, or IKKy.

Aufreinigung: IKK epsilon Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-IKK epsilon antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IKK epsilon. The immunogen is located within the last 50 amino acids of IKK epsilon.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1-2 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IKK epsilon Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IKK epsilon antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu IKKi/IKKe

Target: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Andere Bezeichnung: IKK epsilon (IKBKE Produkte)

Synonyme: zgc:100844 antikoerper, IKBKE antikoerper, MGC130907 antikoerper, IKK-E antikoerper, IKK-i antikoerper, IKKE antikoerper, IKKI antikoerper, AW558201 antikoerper, IKKepsilon antikoerper, Ikki antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon antikoerper, inhibitor of nuclear factor kappa B kinase subunit epsilon antikoerper, inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog antikoerper, inhibitor of kappaB kinase epsilon antikoerper, IKBKE antikoerper, ikbke antikoerper, ikbke.L antikoerper, Ikbke antikoerper

Hintergrund: IKK epsilon Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ,B is associated with Iκ,B proteins in the cell cytoplasm, which inhibit NF-κ,B activity. Iκ,B is phosphorylated by Iκ,B kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ,. A novel molecule in the IKK complex was recently identified and designated IKKε,/IKK-i. IKK epsilon is required for the activation of NF-κ,B by PMA and T cell receptors but not by TNFα, and IL-1. IKKε,/IKK-i message is expressed in a variety of tissues and is inducible by TNFα, IL-1, and LPS.

Molekulargewicht: Predicted: 80kD

Observed: 80 kD kDa

Gen-ID: 9641

UniProt: Q14164

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades