DS-MB-00283 recognizes an extracellular domain of the 55kD human TNF receptor (p55, TNF-R1, CD120a). No binding occurs to the 75kD TNF receptor (CD120b). CD120a is weakly expressed by monocytes and granulocytes. This product may be used to detect high levels of TNFR1, in western blotting under reducing conditions, such as recombinant material, but it is not suitable for detection of TNFR1 in normal cells in this application. The antibody inhibits the biological activity of both natural and recombinant human TNFalpha and TNFbeta (1-3). Removal of sodium azide is recommended prior to use in functional assays. This product is routinely tested in flow cytometry on human peripheral blood monocytes. This product reacts with Rabbit, Antibody reactivity and working conditions may vary between species.
Produktmerkmale
Adhesion Molecule/Cell Surface
Aufreinigung
Purified
Immunogen
Purified human tumour necrosis factor receptor type 1