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TNFRSF1A Antikörper (AA 20-43)

TNFRSF1A Reaktivität: Maus ICC, IF, IP, IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1686656
$452.40
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 3 bis 4 Werktagen
  • Target Alle TNFRSF1A Antikörper anzeigen
    TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
    Bindungsspezifität
    • 16
    • 16
    • 12
    • 11
    • 10
    • 9
    • 8
    • 8
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-43
    Reaktivität
    • 167
    • 86
    • 50
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 139
    • 43
    • 10
    • 8
    • 5
    • 2
    • 1
    Kaninchen
    Klonalität
    • 150
    • 57
    Polyklonal
    Konjugat
    • 97
    • 26
    • 20
    • 13
    • 11
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TNFRSF1A Antikörper ist unkonjugiert
    Applikation
    • 138
    • 91
    • 80
    • 67
    • 50
    • 31
    • 24
    • 23
    • 23
    • 17
    • 15
    • 13
    • 11
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Detects ~55 kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.
    Kreuzreaktivität
    Rind (Kuh), Hund, Human, Affe, Maus, Kaninchen, Ratte
    Aufreinigung
    Peptide Affinity Purified
    Immunogen
    Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1686656 was sufficient for detection of TNFR1 in 20 μg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))
    Andere Bezeichnung
    TNFR1 (TNFRSF1A Produkte)
    Synonyme
    CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60, TNF-R1, TNF-alphaR1, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, fpf, tbp1, p55-r, tnf-r, tnfar, tnfr1, cd120a, tnfr55, tnfr60, xtnfr1, wu:fj65b10, zgc:85914, TNFR I, TNFRSF1A, TNFA, cTNF, TNF receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1a, TNF receptor superfamily member 1A S homeolog, tumor necrosis factor, TNFRSF1A, Tnfrsf1a, tnfrsf1a.S, tnfrsf1a, TNF
    Hintergrund
    The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
    Gen-ID
    8666
    UniProt
    P19438
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Hepatitis C, Ubiquitin Proteasome Pathway
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