TET2 Antikörper (Internal Region)
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- Target Alle TET2 Antikörper anzeigen
- TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
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Bindungsspezifität
- Internal Region
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TET2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- TET2 Antibody detects endogenous levels of total TET2.
- Homologie
- Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TET2, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product TET2 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
- Andere Bezeichnung
- TET2 (TET2 Produkte)
- Synonyme
- KIAA1546 antikoerper, MDS antikoerper, Ayu17-449 antikoerper, E130014J05Rik antikoerper, mKIAA1546 antikoerper, RGD1311625 antikoerper, tet methylcytosine dioxygenase 2 antikoerper, TET2 antikoerper, Tet2 antikoerper
- Hintergrund
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Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Gene: TET2
- Molekulargewicht
- 130 kDa,133 kDa,224 kDa
- Gen-ID
- 54790
- UniProt
- Q6N021
- Pathways
- Warburg Effekt
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