TET2 Antikörper (AA 1-300)

Produktnummer ABIN2668527

Dieser Maus Monoklonal Antikörper detektiert spezifisch TET2 in WB, IP, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für TET2 Antikörper (AA 1-300) (ABIN2668527)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TET2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 21F11

Produktdetails anti-TET2 Antikörper

Bindungsspezifität: AA 1-300

Verwendungszweck: Tet2 antibody (mAb) (Clone 21F11)

Aufreinigung: Protein A Chromatography

Immunogen: This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: IP: 1 - 2 µL per IP WB: 1 - 2 μg/mL dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-TET2 Antikörper (ABIN2668527)

Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: "Epigenetic dynamics of monocyte-to-macrophage differentiation. ..." in: Epigenetics & chromatin, Vol. 9, pp. 33, (2016) (PubMed).

Gong, Guo, Niu, Jin, Zhang, Shi, Zhang, Li, Chen, Ma: "Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma." in: Oncotarget, Vol. 8, Issue 1, pp. 315-328, (2016) (PubMed).

Details zu TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Andere Bezeichnung: Tet2

Hintergrund: Tet2 (tet methylcytosine dioxygenase 2) catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation and differentiation in the case of inflammation by regulating gene expression and macrophage differentiation.

Molekulargewicht: 220 kDa

Gen-ID: 54790

NCBI Accession: NP_001120680

Pathways: Warburg Effekt