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TET2 Antikörper

TET2 Reaktivität: Maus WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7270780
  • Target Alle TET2 Antikörper anzeigen
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    Reaktivität
    • 48
    • 14
    • 6
    Maus
    Wirt
    • 41
    • 8
    • 2
    Kaninchen
    Klonalität
    • 43
    • 8
    Polyklonal
    Konjugat
    • 33
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TET2 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 23
    • 11
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Verwendungszweck
    TET2 Rabbit pAb
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant protein of mouse TET2.
    Isotyp
    IgG
    Top Product
    Discover our top product TET2 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    Andere Bezeichnung
    TET2 (TET2 Produkte)
    Synonyme
    KIAA1546 antikoerper, MDS antikoerper, Ayu17-449 antikoerper, E130014J05Rik antikoerper, mKIAA1546 antikoerper, RGD1311625 antikoerper, tet methylcytosine dioxygenase 2 antikoerper, TET2 antikoerper, Tet2 antikoerper
    Hintergrund
    Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC into 5-hydroxymethylcytosine (5hmC and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC, and conversion of 5fC to 5-carboxylcytosine (5caC. Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.,Ayu17-44, Ayu17-449, mKIAA1546, E130014J05Rik,TET2
    Molekulargewicht
    212kDa
    Gen-ID
    214133
    UniProt
    Q4JK59
    Pathways
    Warburg Effekt
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