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Bcl-2 Antikörper (Internal Region)

Name: Bcl-2 Antikörper (Internal Region)
SKU: ABIN6260221
Price: 698.46 EUR
Availability: InStock

BCL2 Reaktivität: Human WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Western blot analysis on MCF7 cell lysate using BCL-2 Antibody，The lane on the left is treated with the antigen-specific peptide. (Bcl-2 Antikörper (Internal Region))

IF/ICC

ABIN6267001 at 1/100 staining human Lymph node tissue sections by IHC-P. (Bcl-2 Antikörper (Internal Region))

IHC

3 Abbildungen

(1 reference)

Produktnummer ABIN6260221

Datenblatt (PDF)

Target Alle Bcl-2 (BCL2) Antikörper anzeigen

Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
Bindungsspezifität
54

37

23

22

21

18

17

16

16

16

15

14

13

10

8

8

8

8

7

7

7

7

6

6

6

6

6

5

4

4

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
Internal Region
Reaktivität
446

190

186

38

34

22

22

19

17

16

12

5

5

1

1

1
Human
Wirt
349

124

6

2

1

1

1
Kaninchen
Passende Sekundärantikörper
Klonalität
346

137
Polyklonal
Konjugat
216

34

33

25

25

14

14

13

11

11

11

11

9

9

9

9

9

2

2

2

2

2

2

2

2

1

1

1

1

1
Dieser Bcl-2 Antikörper ist unkonjugiert
Applikation
389

201

168

115

107

103

92

74

64

33

29

25

18

8

8

8

5

4

3

2

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität

Bcl-2 Antibody detects endogenous levels of total Bcl-2.

Aufreinigung

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human Bcl-2, corresponding to a region within the internal amino acids.

Isotyp

IgG

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anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 101-160) antibody
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anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 1-100) antibody
BCL2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) antibody
BCL2 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Monoclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibody
BCL2 Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal D1 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody
BCL2 Reaktivität: Human WB, FACS, IHC (p), IP, ICC, IHC (fro) Wirt: Maus Monoclonal Bcl-2-100 unconjugated

Applikationshinweise

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C

Informationen zur Lagerung

Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit

12 months
Mao, Du, Yang, Zhang, Peng, Jiang, Zhou: "Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 208-214, (2018) (PubMed).
Target

Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Andere Bezeichnung

BCL2 (BCL2 Produkte)

Synonyme

Bcl-2 antikoerper, PPP1R50 antikoerper, bcl-2 antikoerper, AW986256 antikoerper, C430015F12Rik antikoerper, D630044D05Rik antikoerper, D830018M01Rik antikoerper, BCL-2 antikoerper, Bcl2 antikoerper, BCL2, apoptosis regulator antikoerper, B cell leukemia/lymphoma 2 antikoerper, B-cell CLL/lymphoma 2a antikoerper, B-cell CLL/lymphoma 2 protein antikoerper, BCL2 antikoerper, Bcl2 antikoerper, bcl2a antikoerper, BCL-2 antikoerper

Hintergrund

Description: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Gene: BCL2

Molekulargewicht

28kDa

Gen-ID

596

UniProt

P10415

Pathways

MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling