TRAF6 Antikörper

Produktnummer ABIN5701257

Produktdetails anti-TRAF6 Antikörper

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: TNF receptor-associated factor 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

A431 cells were subjected to SDS PAGE followed by western blot with FNab08921(TRAF6 antibody) at dilution of 1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu TRAF6

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Andere Bezeichnung: TRAF6 (TRAF6 Produkte)

Synonyme: MGC:3310 antikoerper, RNF85 antikoerper, 2310003F17Rik antikoerper, AI851288 antikoerper, C630032O20Rik antikoerper, rnf85 antikoerper, traf6 antikoerper, xtraf6 antikoerper, CG10961 antikoerper, DTRAF2 antikoerper, Dmel\\CG10961 antikoerper, TRAF antikoerper, TRAF2 antikoerper, TRAF6 antikoerper, Traf2 antikoerper, dTRAF2 antikoerper, dTRAF6 antikoerper, dTraf2 antikoerper, dtraf2 antikoerper, GB10539 antikoerper, fi15f02 antikoerper, wu:fi15f02 antikoerper, zgc:63704 antikoerper, TNF receptor associated factor 6 antikoerper, TNF receptor-associated factor 6 antikoerper, TNF receptor associated factor 6 L homeolog antikoerper, TNF-receptor-associated factor 6 antikoerper, TNF receptor associated factor 6 S homeolog antikoerper, TRAF6 antikoerper, Traf6 antikoerper, traf6.L antikoerper, traf6 antikoerper, LOC551819 antikoerper, traf6.S antikoerper

Hintergrund: Synonyms:RING finger protein 85, RNF85, TRAF6 Background:E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells(DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1(AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Gen-ID: 7189

UniProt: Q9Y4K3

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway