MAVS Antikörper (AA 160-450)

Produktnummer ABIN5688365

Produktdetails anti-MAVS Antikörper

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Bindungsspezifität: AA 160-450

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAVS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Spezifität: Recognizes human Cardif.

Reinheit: > 95% (SDS-PAGE)

Immunogen: Recombinant human Cardif (aa 160-450).

Klon: Adri-1

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Immunocytochemistry: (1:100). Immunohistochemistry: (paraffin sections). Immunoprecipitation: (1:200). Western Blot: (1:1,000).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least 1 year after receipt when stored at -20°C.

Details zu MAVS

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Andere Bezeichnung: Cardif (MAVS Produkte)

Synonyme: CARDIF antikoerper, IPS-1 antikoerper, IPS1 antikoerper, VISA antikoerper, D430028G21Rik antikoerper, Visa antikoerper, cardif antikoerper, wu:fj20d04 antikoerper, zgc:158392 antikoerper, mitochondrial antiviral signaling protein antikoerper, MAVS antikoerper, Mavs antikoerper, mavs antikoerper

Hintergrund: RIG-I (retinoic acid-inducible gene I, Ddx58) and MDA5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a new CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and MDA5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondrial outer membrane. Removal of the mitochondrial-targeting domain of cardif abolishes its ability to induce IFNs. Cardif is cleaved and inactivated by NS3-4A, a serine protease from hepatitis C virus known to block interferon-beta production.

Gen-ID: 57506

NCBI Accession: NP_065797

UniProt: Q7Z434

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C