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MAVS Antikörper (N-Term)

MAVS Reaktivität: Human, Maus, Rind (Kuh) WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2783802
  • Target Alle MAVS Antikörper anzeigen
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Bindungsspezifität
    • 15
    • 13
    • 8
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 48
    • 37
    • 4
    • 1
    • 1
    Human, Maus, Rind (Kuh)
    Wirt
    • 69
    • 7
    Kaninchen
    Klonalität
    • 71
    • 5
    Polyklonal
    Konjugat
    • 34
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAVS Antikörper ist unkonjugiert
    Applikation
    • 68
    • 37
    • 13
    • 13
    • 11
    • 9
    • 8
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    ETQAPESPGE NSEQALQTLS PRAIPRNPDG GPLESSSDLA ALSPLTSSGH
    Homologie
    Cow: 79%, Human: 100%, Mouse: 79%
    Produktmerkmale
    This is a rabbit polyclonal antibody against VISA. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human VISA
    Top Product
    Discover our top product MAVS Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 896 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Andere Bezeichnung
    VISA (MAVS Produkte)
    Synonyme
    CARDIF antikoerper, IPS-1 antikoerper, IPS1 antikoerper, VISA antikoerper, D430028G21Rik antikoerper, Visa antikoerper, cardif antikoerper, wu:fj20d04 antikoerper, zgc:158392 antikoerper, mitochondrial antiviral signaling protein antikoerper, MAVS antikoerper, Mavs antikoerper, mavs antikoerper
    Hintergrund
    Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3, MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK, MIM 600664) and IKKB (IKBKB, MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE, MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1, MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1, MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CARDIF, DKFZp666M015, FLJ27482, FLJ41962, IPS-1, KIAA1271, MAVS, IPS1, VISA
    Protein Interaction Partner: MIB2, KCNIP3, DDX58, UBC, TRAF6, TRAF3, UBXN1, TMEM173, SMURF2, HCVgp1, AMFR, MFN1, MFN2, MUL1, TOMM70A, FLOT2, NDFIP1, SMURF1, TBK1, IKBKG, TICAM1, TRAF2, MAP3K7, SRC, IRF7, IRF3, IKBKE, TSPAN6, RARRES3, ECSIT, PCBP2, ITCH, IFIH1, PSMA7, WDR5, HECTD3, PD
    Protein Size: 896
    Molekulargewicht
    56 kDa
    Gen-ID
    57506
    NCBI Accession
    NM_020746, NP_065797
    UniProt
    Q2HWT5
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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