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MDM2 Antikörper (Middle Region)
MDM2
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN5517680
Produktdetails anti-MDM2 Antikörper
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Target
Alle MDM2 Antikörper anzeigen
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Bindungsspezifität
Alle Epitope für MDM2 Antikörper
Middle Region
Reaktivität
Alle Reaktivitäten für MDM2 Antikörper
Human
Wirt
Alle Wirte für MDM2 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für MDM2 Antikörper
Polyklonal
Konjugat
Alle Konjugate für MDM2 Antikörper
Dieser MDM2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MDM2 Antikörper
Western Blotting (WB)
Sequenz
EISLADYWKC TSCNEMNPPL PSHCNRCWAL RENWLPEDKG KDKGEISEKA
Produktmerkmale
This is a rabbit polyclonal antibody against MDM2. It was validated on Western Blot.
Aufreinigung
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human MDM2
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Discover our top product MDM2 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu MDM2
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Target
MDM2
(Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))
Andere Bezeichnung
MDM2 (MDM2 Produkte )
Synonyme
ACTFS antikoerper, HDMX antikoerper, hdm2 antikoerper, zgc:109834 antikoerper, 1700007J15Rik antikoerper, AA415488 antikoerper, Mdm-2 antikoerper, MDM2 proto-oncogene antikoerper, MDM2 proto-oncogene S homeolog antikoerper, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antikoerper, MDM2 oncogene, E3 ubiquitin protein ligase antikoerper, transformed mouse 3T3 cell double minute 2 antikoerper, MDM2 antikoerper, mdm2.S antikoerper, Mdm2 antikoerper, mdm2 antikoerper
Hintergrund
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. Alias Symbols: MDM2, Protein Interaction Partner: RPS7, RPS6, RPL26, UBE2D3, UBE2D2, UBE2D1, UBC, CDKN2A, HDAC1, TSC22D3, DAPK3, PARP1, PML, ARIH2, RPL23, KAT2B, AATF, RCHY1, DLAT, DHX9, DDX5, DAXX, U19, HRNR, OGDH, NCL, HNRNPM, MDM4, MDM2, ILF3, IFI16, IARS, HSP90AB1, HSP90AA1, HSPA8, HNRNPU, GTF2I, PER Protein Size: 446
Gen-ID
4193
Pathways
p53 Signalweg , PI3K-Akt Signalweg , Zellzyklus , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Autophagie , Ubiquitin Proteasome Pathway
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