ATG14 Antikörper (Middle Region)

Produktnummer ABIN5516479

Produktdetails anti-ATG14 Antikörper

Target: ATG14 (ATG14 Autophagy Related 14 (ATG14))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATG14

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATG14

Target: ATG14 (ATG14 Autophagy Related 14 (ATG14))

Andere Bezeichnung: ATG14 (ATG14 Produkte)

Synonyme: ATG14L antikoerper, BARKOR antikoerper, KIAA0831 antikoerper, 4832427M01 antikoerper, Atg14L antikoerper, D14Ertd114e antikoerper, D14Ertd436e antikoerper, RGD1304610 antikoerper, autophagy related 14 antikoerper, ATG14 antikoerper, Atg14 antikoerper

Hintergrund: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism.

Alias Symbols: ATG14L, BARKOR, KIAA0831

Protein Size: 492

Gen-ID: 22863

NCBI Accession: NM_014924, NP_055739

UniProt: Q6ZNE5

Pathways: Autophagie