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MECP2 Antikörper (N-Term)
MECP2
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN5515594
Produktdetails anti-MECP2 Antikörper
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Target
Alle MECP2 Antikörper anzeigen
MECP2
(Methyl CpG Binding Protein 2 (MECP2))
Bindungsspezifität
Alle Epitope für MECP2 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für MECP2 Antikörper
Human
Wirt
Alle Wirte für MECP2 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für MECP2 Antikörper
Polyklonal
Konjugat
Alle Konjugate für MECP2 Antikörper
Dieser MECP2 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für MECP2 Antikörper
Western Blotting (WB)
Sequenz
LDPNDFDFTV TGRGSPSRRE QKPPKKPKSP KAPGTGRGRG RPKGSGTTRP
Produktmerkmale
This is a rabbit polyclonal antibody against MECP2. It was validated on Western Blot.
Aufreinigung
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human MECP2
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Discover our top product MECP2 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu MECP2
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Target
MECP2
(Methyl CpG Binding Protein 2 (MECP2))
Andere Bezeichnung
MECP2 (MECP2 Produkte )
Synonyme
AUTSX3 antikoerper, MRX16 antikoerper, MRX79 antikoerper, MRXS13 antikoerper, MRXSL antikoerper, PPMX antikoerper, RS antikoerper, RTS antikoerper, RTT antikoerper, 1500041B07Rik antikoerper, BB130002 antikoerper, D630021H01Rik antikoerper, Mbd5 antikoerper, WBP10 antikoerper, wu:fk96a04 antikoerper, zgc:111857 antikoerper, methyl-CpG binding protein 2 antikoerper, methyl CpG binding protein 2 antikoerper, methyl-CpG binding protein 2 S homeolog antikoerper, MECP2 antikoerper, Mecp2 antikoerper, mecp2 antikoerper, mecp2.S antikoerper
Hintergrund
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Protein Size: 486
Gen-ID
4204
NCBI Accession
XP_005274738
UniProt
P51608
Pathways
Inositol Metabolic Process , Chromatin Binding , Synaptic Membrane
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