SMAD4 Antikörper (Thr277)

Produktnummer ABIN542927

Produktdetails anti-SMAD4 Antikörper

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Bindungsspezifität: Thr277

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic peptide of SMAD4.

Kreuzreaktivität: Human

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to residues surrounding T277 of human SMAD4.

Anwendungsinformationen

Applikationshinweise: Dot Blot (1:500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-SMAD4 Antikörper (ABIN542927)

Zhang, Lui: "Transforming growth factor-?3 regulates cell junction restructuring via MAPK-mediated mRNA destabilization and Smad-dependent protein degradation of junctional adhesion molecule B (JAM-B)." in: Biochimica et biophysica acta, Vol. 1849, Issue 6, pp. 601-11, (2015) (PubMed).

Xiao, Ho, Liong, Nanji, Leung, Lau, Fung, Tipoe: "Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways." in: European journal of nutrition, Vol. 53, Issue 1, pp. 187-99, (2014) (PubMed).

Xiao, Xing, Huo, Fung, Liong, Ching, Xu, Chang, So, Tipoe: "Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model." in: Scientific reports, Vol. 4, pp. 5587, (2014) (PubMed).

Wang, Lui: "Transforming growth factor-?1 attenuates junctional adhesion molecule-A and contributes to breast cancer cell invasion." in: European journal of cancer (Oxford, England : 1990), Vol. 48, Issue 18, pp. 3475-87, (2012) (PubMed).

Horvath, Henshall, Kench, Turner, Golovsky, Brenner, ONeill, Kooner, Stricker, Grygiel, Sutherland: "Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression." in: The Prostate, Vol. 59, Issue 3, pp. 234-42, (2004) (PubMed).

Sekiya, Oda, Matsuura, Akiyama: "Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling." in: Biochemical and biophysical research communications, Vol. 320, Issue 3, pp. 680-4, (2004) (PubMed).

Li, Xin, Xu, Huang, Zhang, Chen, Zhang, Fu, Chang: "CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 856-64, (2003) (PubMed).

Details zu SMAD4

Target: SMAD4 (SMAD Family Member 4 (SMAD4))

Andere Bezeichnung: SMAD4 (SMAD4 Produkte)

Synonyme: smad4 antikoerper, DPC4 antikoerper, JIP antikoerper, MADH4 antikoerper, MYHRS antikoerper, AW743858 antikoerper, D18Wsu70e antikoerper, Madh4 antikoerper, XSmad4alpha antikoerper, Xsmad4 antikoerper, dpc4 antikoerper, jip antikoerper, madh4 antikoerper, xsmad4a antikoerper, SMAD family member 4 antikoerper, Smad4 protein antikoerper, SMAD family member 4, gene 1 L homeolog antikoerper, SMAD4 antikoerper, smad4 antikoerper, Smad4 antikoerper, smad4.1.L antikoerper

Gen-ID: 4089

Pathways: Zellzyklus, Chromatin Binding, Autophagie