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SMAD4 Produkte

(SMAD Family Member 4 (SMAD4))
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009].

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Ausgewählte SMAD4 Kategorien

SMAD4 Antikörper

High quality antibodies with extensive validation data.

SMAD4 ELISA Kits

Reliable ELISA kits for a wide range of species.

SMAD4 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene SMAD4 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation FACS, IF, IHC, ELISA, WB
Validierungen
  • (6)
Kat. Nr. ABIN3032608
Menge 0.4 mL
Datenblatt Datenblatt
Reaktivität Human
Applikation IF, PLA, ELISA, WB
Validierungen
  • (8)
Kat. Nr. ABIN561723
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ICC, FACS, IHC, ELISA, WB
Validierungen
  • (2)
  • (4)
Kat. Nr. ABIN969403
Menge 100 μL
Datenblatt Datenblatt

Empfohlene SMAD4 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970245
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970244
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6962162
Menge 96 tests
Datenblatt Datenblatt

Empfohlene SMAD4 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1320605
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN2732222
Menge 20 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3095493
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren SMAD4 Produkten

Tumelty, Higginson-Scott, Fan, Bajaj, Knowlton, Shamashkin, Coyle, Lu, Berasi: "Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways." in: The Journal of biological chemistry, Vol. 293, Issue 9, pp. 3039-3055, (2019) (PubMed).

Yamaguchi, Mino-Kenudson, Liss, Chowdhury, Wang, Fernández-Del Castillo, Lillemoe, Warshaw, Thayer: "Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice." in: Gastroenterology, Vol. 151, Issue 6, pp. 1232-1244.e10, (2016) (PubMed).

Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: "M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo." in: Translational research : the journal of laboratory and clinical medicine, Vol. 170, pp. 99-111, (2016) (PubMed).

Geng, Chen, Yuan, Peng, Maitra, Diao, Chen, Zhang, Hu, Qi, Pierce, Ling, Xiong, Li: "The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis." in: Nature communications, Vol. 7, pp. 13436, (2016) (PubMed).

Arjunan, Gnanaprakasam, Ananth, Romej, Rajalakshmi, Prasad, Martin, Gurusamy, Thangaraju, Bhutia, Ganapathy: "Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis." in: Investigative ophthalmology & visual science, Vol. 57, Issue 4, pp. 1612-9, (2016) (PubMed).

Xu, Xu, Saud, Lu, Liu, Fang, Zhang, Hu, Li: "Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in Patients with Ulcerative Colitis." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 2601830, (2016) (PubMed).

Zhang, Lui: "Transforming growth factor-?3 regulates cell junction restructuring via MAPK-mediated mRNA destabilization and Smad-dependent protein degradation of junctional adhesion molecule B (JAM-B)." in: Biochimica et biophysica acta, Vol. 1849, Issue 6, pp. 601-11, (2015) (PubMed).

Cheng, Xiao, Ainiwaer, Wang, Wu, Mao, Yang, Bao: "Molecular responses of radiation-induced liver damage in rats." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 2592-600, (2015) (PubMed).

Xiao, Ho, Liong, Nanji, Leung, Lau, Fung, Tipoe: "Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways." in: European journal of nutrition, Vol. 53, Issue 1, pp. 187-99, (2014) (PubMed).

Xiao, Xing, Huo, Fung, Liong, Ching, Xu, Chang, So, Tipoe: "Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model." in: Scientific reports, Vol. 4, pp. 5587, (2014) (PubMed).

Synonyme und alternative Namen zu SMAD4

SMAD family member 4 (SMAD4), Smad4 protein (smad4), SMAD family member 4 (Smad4), SMAD family member 4, gene 1 L homeolog (smad4.1.L), AW743858, D18Wsu70e, DPC4, dpc4, JIP, jip, MADH4, Madh4, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha

Bezeichner auf Proteinebene für SMAD4

  • Mothers against decapentaplegic-like protein 4
  • mothers against decapentaplegic homolog 4
  • Smad4 protein
  • SMAD family member 4
  • mothers against decapentaplegic homolog 4-like
  • MAD homolog 4
  • SMAD, mothers against DPP homolog 4
  • deleted in pancreatic carcinoma locus 4
  • deletion target in pancreatic carcinoma 4
  • mothers against decapentaplegic, Drosophila, homolog of, 4
  • Smad 4
  • deletion target in pancreatic carcinoma 4 homolog
  • mothers against DPP homolog 4
  • MAD (mothers against decapentaplegic Drosophila) homolog 4
  • SMAD 4
  • MAD, mothers against decapentaplegic homolog 4
  • mothers against DPP-like 4
  • mothers against decapentaplegic-like 4
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