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SMAD2 Produkte

(SMAD, Mothers Against DPP Homolog 2 (SMAD2))
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

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Ausgewählte SMAD2 Kategorien

SMAD2 Antikörper

High quality antibodies with extensive validation data.

SMAD2 ELISA Kits

Reliable ELISA kits for a wide range of species.

SMAD2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene SMAD2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ICC, FACS, IHC, ELISA, WB
Validierungen
  • (2)
  • (7)
Kat. Nr. ABIN969401
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC, WB
Validierungen
  • (6)
Kat. Nr. ABIN7160228
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ELISA, ICC, IF, IHC, WB
Validierungen
  • (6)
Kat. Nr. ABIN6265170
Menge 100 μL
Datenblatt Datenblatt

Empfohlene SMAD2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6959520
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN6959523
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970250
Menge 96 tests
Datenblatt Datenblatt

Empfohlene SMAD2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN2732219
Menge 20 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Baculovirus infected Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN7320169
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3135556
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren SMAD2 Produkten

Chen, Ma, He, Xing, Liu, Yang, Zhu, Wang, Wen: "The TGF-β1 pathway is early involved in neurogenic bladder fibrosis of juvenile rats." in: Pediatric research, Vol. 90, Issue 4, pp. 759-767, (2022) (PubMed).

Liang, Lu, Yu, Zhu, Xie, Wang, Ye, Li, Liu, Liu, Zhu: "Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling." in: Journal of bone and mineral metabolism, Vol. 40, Issue 1, pp. 40-55, (2022) (PubMed).

Guo, Lai, Wang, Huang, Chen, Geng, Huang, Luo, Wu, Ling, Huang, Du, Weng: "Extracellular vesicles derived from mesenchymal stem cells prevent skin fibrosis in the cGVHD mouse model by suppressing the activation of macrophages and B cells immune response." in: International immunopharmacology, Vol. 84, pp. 106541, (2021) (PubMed).

Pennarossa, Manzoni, Ledda, deEguileor, Gandolfi, Brevini: "Use of a PTFE Micro-Bioreactor to Promote 3D Cell Rearrangement and Maintain High Plasticity in Epigenetically Erased Fibroblasts." in: Stem cell reviews, Vol. 15, Issue 1, pp. 82-92, (2019) (PubMed).

Caja, Tzavlaki, Dadras, Tan, Hatem, Maturi, Morén, Wik, Watanabe, Savary, Kamali-Moghaddan, Uhrbom, Heldin, Moustakas: "Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells." in: Oncogene, Vol. 37, Issue 19, pp. 2515-2531, (2019) (PubMed).

Shao, Song, Hua, Zhang, Sun, Kong, Wang, Luo, Jiang: "Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion." in: Cell death & disease, Vol. 9, Issue 6, pp. 625, (2018) (PubMed).

Xing, Yu, Zhang, Luo, Lei, Huang, Lin, Huang, Huang, Nong, Zhou, Wei et al.: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." in: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).

Liu, Zhang, Su, Wang, Liu, Kong: "Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction." in: Biomedicine & pharmacotherapy, Vol. 102, pp. 633-638, (2018) (PubMed).

Xiao, Ye, Zhou, Huang, Liu, Huang, Zhu, Wu, Zhang, Cai: "Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway." in: Archives of biochemistry and biophysics, Vol. 640, pp. 37-46, (2018) (PubMed).

Pang, Li, Mo, Huang, Deng, Lei, Zheng, Feng, Xie, Gao: "IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation." in: BMC gastroenterology, Vol. 18, Issue 1, pp. 61, (2018) (PubMed).

Synonyme und alternative Namen zu SMAD2

SMAD family member 2 (SMAD2), SMAD family member 2-Z (SMAD2Z), SMAD family member 2 (smad2), SMAD family member 2 S homeolog (smad2.S), SMAD family member 2 (Smad2), 7120426M23Rik, fj43c06, hMAD-2, hmad-2, hSMAD2, hsmad2, JV18, jv18, JV18-1, jv18-1, MADH2, madh2, Madh2, MAD homolog 2, MADR2, madr2, Madr2, mMad2, Mothers against DPP homolog 2, smad-2, Smad-2, SMAD 2, Smad2, wu:fj43c06, Xmad2, XSmad2

Bezeichner auf Proteinebene für SMAD2

  • MAD homolog 2
  • SMAD, mothers against DPP homolog 2
  • Sma- and Mad-related protein 2
  • mother against DPP homolog 2
  • mothers against decapentaplegic homolog 2
  • SMAD 2
  • mothers against DPP homolog 2
  • mothers against decapentaplegic-like 2
  • MAD (mothers against decapentaplegic, Drosophila) homolog 2
  • SMA- and MAD-related protein 2
  • SMAD family member 2
  • Smad 2
  • mad-related protein 2
  • LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2
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