Cullin 2 Antikörper (C-Term)

Produktnummer ABIN498035

Produktdetails anti-Cullin 2 Antikörper

Target: Cullin 2 (CUL2)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Cullin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-QYIERSQASA DE

Spezifität: Recognizes CUL2 (C-term).

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_003582.2 Genename: CUL2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit Dilution: 1/8000. Western blot: 1-3 μg/mL. Approx 100 kDa band observed in lysates of cell line NIH3T3(calculated MW of 87.0 kDa according to Human NP_003582.2 and of 86.0 kDa according toMouse NP_083678.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Cullin 2

Target: Cullin 2 (CUL2)

Andere Bezeichnung: Cullin-2 (CUL2 Produkte)

Synonyme: cul2 antikoerper, Cullin-2 antikoerper, fj48a06 antikoerper, wu:fj48a06 antikoerper, cullin-2 antikoerper, LOC100221330 antikoerper, 1300003D18Rik antikoerper, 4932411N15Rik antikoerper, AI327301 antikoerper, mKIAA4106 antikoerper, ATCUL2 antikoerper, F22D16.2 antikoerper, F22D16_2 antikoerper, cullin 2 antikoerper, cullin 2 antikoerper, cullin-2 antikoerper, putative cullin-2 (cul-2) antikoerper, cullin 2 L homeolog antikoerper, Cullin-2 antikoerper, cul2 antikoerper, CUL2 antikoerper, PTRG_05231 antikoerper, Smp_079740 antikoerper, LOC100550749 antikoerper, Cul2 antikoerper, cul2.L antikoerper, cul-2 antikoerper

Hintergrund: Cullin 2 is a member of the family of human Cullin genes (CUL1, 2, 3, 4a, 4b and 5) homologous to the S. cerevisiae cdc53 gene. It is a component of E3 ubiquitin ligase complexes, including the inactive transcriptional elongation complex SIII, which mediates the ubiquitination of hypoxia-inducible factor (HIF). SIII is formed by three subunits: Elongin C, Elongin B and VHL. Cullin 2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.Synonyms: CUL-2, CUL2

Gen-ID: 8453

NCBI Accession: NP_003582

UniProt: Q13617

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interaktom