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Cullin 2 Antikörper (N-Term)

CUL2 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB33843 unconjugated
Produktnummer ABIN1539078
  • Target Alle Cullin 2 (CUL2) Antikörper anzeigen
    Cullin 2 (CUL2)
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 150-179, N-Term
    Reaktivität
    • 76
    • 39
    • 25
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Human, Maus
    Wirt
    • 72
    • 3
    • 1
    Kaninchen
    Klonalität
    • 64
    • 12
    Polyklonal
    Konjugat
    • 33
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cullin 2 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 29
    • 14
    • 14
    • 13
    • 12
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CUL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the N-terminal region of human CUL2.
    Klon
    RB33843
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    CUL2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Haltbarkeit
    6 months
  • Target
    Cullin 2 (CUL2)
    Andere Bezeichnung
    CUL2 (CUL2 Produkte)
    Synonyme
    cul2 antikoerper, Cullin-2 antikoerper, fj48a06 antikoerper, wu:fj48a06 antikoerper, cullin-2 antikoerper, LOC100221330 antikoerper, 1300003D18Rik antikoerper, 4932411N15Rik antikoerper, AI327301 antikoerper, mKIAA4106 antikoerper, ATCUL2 antikoerper, F22D16.2 antikoerper, F22D16_2 antikoerper, cullin 2 antikoerper, cullin 2 antikoerper, cullin-2 antikoerper, putative cullin-2 (cul-2) antikoerper, cullin 2 L homeolog antikoerper, Cullin-2 antikoerper, cul2 antikoerper, CUL2 antikoerper, PTRG_05231 antikoerper, Smp_079740 antikoerper, LOC100550749 antikoerper, Cul2 antikoerper, cul2.L antikoerper, cul-2 antikoerper
    Hintergrund
    Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
    Molekulargewicht
    86983
    Gen-ID
    8453
    NCBI Accession
    NP_001185706, NP_001185707, NP_001185708, NP_003582
    UniProt
    Q13617
    Pathways
    M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interaktom
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