AKT3 Antikörper (AA 88-118)

Produktnummer ABIN3029482

Produktdetails anti-AKT3 Antikörper

Target: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Bindungsspezifität: AA 88-118

Reaktivität: Human, Maus, Ratte, Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Purified

Immunogen: A portion of amino acids 88-118 from the human protein was used as the immunogen for this AKT3 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the AKT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the AKT3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu AKT3

Target: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Andere Bezeichnung: AKT3 (AKT3 Produkte)

Synonyme: MPPH antikoerper, PKB-GAMMA antikoerper, PKBG antikoerper, PRKBG antikoerper, RAC-PK-gamma antikoerper, RAC-gamma antikoerper, STK-2 antikoerper, AI851531 antikoerper, D930002M15Rik antikoerper, Nmf350 antikoerper, Pkbg antikoerper, AKT serine/threonine kinase 3 antikoerper, thymoma viral proto-oncogene 3 antikoerper, v-akt murine thymoma viral oncogene homolog 3b antikoerper, AKT3 antikoerper, Akt3 antikoerper, akt3b antikoerper

Hintergrund: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. [UniProt]

UniProt: Q9Y243

Pathways: PI3K-Akt Signalweg, RTK Signalweg, TLR Signalweg, Hepatitis C, VEGF Signaling