MDM2 Antikörper (Ser166)

Produktnummer ABIN540533

Produktdetails anti-MDM2 Antikörper

Target: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Bindungsspezifität: Ser166

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDM2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic peptide of MDM2.

Sequenz: AISET

Spezifität: MDM2 (Ab-166) Antibody detects endogenous levels of total MDM2 protein.

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Antibody Reactive Against Synthetic Peptide.

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S166 of human MDM2.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50 % glycerol, 0.02 % sodium azide)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-MDM2 Antikörper (ABIN540533)

Mayo, Donner: "A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11598-603, (2001) (PubMed).

Zhou, Liao, Xia, Zou, Spohn, Hung: "HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation." in: Nature cell biology, Vol. 3, Issue 11, pp. 973-82, (2001) (PubMed).

Details zu MDM2

Target: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Andere Bezeichnung: MDM2 (MDM2 Produkte)

Synonyme: ACTFS antikoerper, HDMX antikoerper, hdm2 antikoerper, zgc:109834 antikoerper, 1700007J15Rik antikoerper, AA415488 antikoerper, Mdm-2 antikoerper, MDM2 proto-oncogene antikoerper, MDM2 proto-oncogene S homeolog antikoerper, Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) antikoerper, MDM2 oncogene, E3 ubiquitin protein ligase antikoerper, transformed mouse 3T3 cell double minute 2 antikoerper, MDM2 antikoerper, mdm2.S antikoerper, Mdm2 antikoerper, mdm2 antikoerper

Gen-ID: 4193

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Autophagie, Ubiquitin Proteasome Pathway