TLR4 Antikörper
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- Target Alle TLR4 Antikörper anzeigen
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TLR4 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), ELISA
- Spezifität
- Human Toll-like Receptor 4 (TLR4) The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLR4 is involved in the recognition of lipopolysaccharide (LPS), an abundant glycolipid of Gram-negative bacteria. Through its association with MD-2 and CD14, TLR4 recognizes and initiates multiple intracellular signaling events such as the activation of NF-B leading to the ultimate synthesis and release of a number of proinflammatory mediators including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α). TLR4 has also been associated in the recognition of and lipocheic acid (LTA), Hsp60 and Hsp70.1-10
- Produktmerkmale
- Mouse Anti-Human TLR4-UNLB
- Aufreinigung
- Purified
- Klon
- 1E11
- Isotyp
- IgG2a
- Top Product
- Discover our top product TLR4 Primärantikörper
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- Applikationshinweise
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- Applications: Enzyme-Linked-Immunosorbent-Assay (ELISA) Flow Cytometry
- Working Dilutions: ELISA: Purified antibody 1:2000-1:4,000 Flow: Purified antibody ≤3 μg/106 cells
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- Konservierungsmittel
- Without preservative
- Handhabung
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C
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- Target
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Andere Bezeichnung
- TLR4 (TLR4 Produkte)
- Synonyme
- ARMD10 antikoerper, CD284 antikoerper, TLR-4 antikoerper, TOLL antikoerper, Lps antikoerper, Ly87 antikoerper, Ran/M1 antikoerper, Rasl2-8 antikoerper, toll like receptor 4 antikoerper, toll-like receptor 4 antikoerper, TLR4 antikoerper, Tlr4 antikoerper
- Hintergrund
- The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLR4 is involved in the recognition of lipopolysaccharide (LPS), an abundant glycolipid of Gram-negative bacteria. Through its association with MD-2 and CD14, TLR4 recognizes and initiates multiple intracellular signaling events such as the activation of NF- κB leading to the ultimate synthesis and release of a number of proinflammatory mediators including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor- α (TNF-α). TLR4 has also been associated in the recognition of and lipocheic acid (LTA), Hsp60 and Hsp70.
- Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine
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