GSK3 alpha Antikörper (N-Term)

Produktnummer ABIN375590

Produktdetails anti-GSK3 alpha Antikörper

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GSK3 alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Human/Mouse GSK-3α

Produktmerkmale: Mouse Anti-GSK-3a-UNLB

Aufreinigung: Purified

Immunogen: Recombinant N-terminal GSK-3alpha

Klon: SBGSK3a1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• Applications: WB - Quality tested
• Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL HRP conjugate 1:1,000 - 1:5,000

Probenmenge: 0,2 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Details zu GSK3 alpha

Target: GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))

Andere Bezeichnung: GSK-3a (GSK3a Produkte)

Synonyme: 2700086H06Rik antikoerper, GSK3A antikoerper, GSK-3[a] antikoerper, GSK-3[b] antikoerper, GSK3 antikoerper, gsk3a antikoerper, xgsk3 antikoerper, glycogen synthase kinase 3 alpha antikoerper, glycogen synthase kinase 3 alpha b antikoerper, glycogen synthase kinase 3 alpha S homeolog antikoerper, GSK3A antikoerper, Gsk3a antikoerper, gsk3a antikoerper, gsk3ab antikoerper, gsk3a.S antikoerper, Bm1_31380 antikoerper

Hintergrund: Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 α and GSK-3β. The two isoforms share 97 % sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Pathways: PI3K-Akt Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effekt