NPM1 Antikörper (C-Term)

Produktnummer ABIN374536

Produktdetails anti-NPM1 Antikörper

Target: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Schimpanse

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser NPM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-QEAIQDLWQW RKSL

Spezifität: This antibody recognizes Nucleophosmin.

Kreuzreaktivität (Details): Species reactivity (expected):Canine, Bovine.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_002511.1, NP_954654.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/2000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu NPM1

Target: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Andere Bezeichnung: Nucleophosmin (NPM1 Produkte)

Synonyme: B23 antikoerper, NPM antikoerper, NO38 antikoerper, Npm antikoerper, B23NP antikoerper, npm4 antikoerper, npm antikoerper, CG7917 antikoerper, CRP1 antikoerper, Crp1 antikoerper, Dmel\\CG7917 antikoerper, dNLP antikoerper, dNLP-S antikoerper, p22 antikoerper, npm1 antikoerper, sb:cb487 antikoerper, nucleophosmin 1 antikoerper, nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog antikoerper, nucleophosmin 1b antikoerper, Nucleophosmin antikoerper, nucleophosmin antikoerper, nucleophosmin (nucleolar phosphoprotein B23, numatrin) antikoerper, Nucleoplasmin antikoerper, nucleophosmin 1a antikoerper, NPM1 antikoerper, Npm1 antikoerper, npm1.L antikoerper, npm1b antikoerper, npm antikoerper, Nlp antikoerper, npm1a antikoerper

Hintergrund: Nucleophosmin (NPM) also called B23, nutramin and NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus and cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.Synonyms: NPM, NPM1, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin

Gen-ID: 4869

NCBI Accession: NP_002511

UniProt: P06748

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly