TNFRSF1A Antikörper (pSer274)

Produktnummer ABIN358242

Produktdetails anti-TNFRSF1A Antikörper

Target: TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))

Bindungsspezifität: pSer274

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects TNFR pSer274.

Aufreinigung: Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S274 of human TNFR.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu TNFRSF1A

Target: TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A))

Andere Bezeichnung: CD120a / TNFR1 (TNFRSF1A Produkte)

Synonyme: CD120a antikoerper, FPF antikoerper, MS5 antikoerper, TBP1 antikoerper, TNF-R antikoerper, TNF-R-I antikoerper, TNF-R55 antikoerper, TNFAR antikoerper, TNFR1 antikoerper, TNFR1-d2 antikoerper, TNFR55 antikoerper, TNFR60 antikoerper, p55 antikoerper, p55-R antikoerper, p60 antikoerper, TNF-R1 antikoerper, TNF-alphaR1 antikoerper, TNFRI antikoerper, TNFRp55 antikoerper, TNFalpha-R1 antikoerper, Tnfr-2 antikoerper, Tnfr1 antikoerper, fpf antikoerper, tbp1 antikoerper, p55-r antikoerper, tnf-r antikoerper, tnfar antikoerper, tnfr1 antikoerper, cd120a antikoerper, tnfr55 antikoerper, tnfr60 antikoerper, xtnfr1 antikoerper, wu:fj65b10 antikoerper, zgc:85914 antikoerper, TNFR I antikoerper, TNFRSF1A antikoerper, TNFA antikoerper, cTNF antikoerper, TNF receptor superfamily member 1A antikoerper, tumor necrosis factor receptor superfamily, member 1a antikoerper, TNF receptor superfamily member 1A S homeolog antikoerper, tumor necrosis factor antikoerper, TNFRSF1A antikoerper, Tnfrsf1a antikoerper, tnfrsf1a.S antikoerper, tnfrsf1a antikoerper, TNF antikoerper

Hintergrund: A member of the TNF-receptor superfamily, this protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.Synonyms: TNF-R1, TNF-RI, TNFR-I, Tnfrsf1a, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I, p55, p60

Molekulargewicht: 50495 Da

Gen-ID: 7132, 9606

UniProt: P19438

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Hepatitis C, Ubiquitin Proteasome Pathway