ERCC2 Antikörper (N-Term)

Produktnummer ABIN504641

Produktdetails anti-ERCC2 Antikörper

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KLNVDGLLVY FPYDYIYPEQ FSYMRELKRT LDAKGHGVLE MPSGTGKTVS

Kreuzreaktivität: Rind (Kuh), Fruchtfliege (Drosophila melanogaster), Human, Maus, Schwein, Ratte (Rattus)

Homologie: Cow: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ERCC2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC2

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-ERCC2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Human Muscle.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 760 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ERCC2

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Andere Bezeichnung: ERCC2 (ERCC2 Produkte)

Synonyme: COFS2 antikoerper, EM9 antikoerper, TTD antikoerper, XPD antikoerper, AA407812 antikoerper, AU020867 antikoerper, AW240756 antikoerper, CXPD antikoerper, Ercc-2 antikoerper, MGC89573 antikoerper, CG9433 antikoerper, DhR3 antikoerper, DhXPD antikoerper, DmXPD antikoerper, Dmel\\CG9433 antikoerper, ERCC2 antikoerper, XPD/ERCC2 antikoerper, l(2)SH2 2137 antikoerper, l(2)SH2137 antikoerper, xpd antikoerper, zgc:56365 antikoerper, ERCC excision repair 2, TFIIH core complex helicase subunit antikoerper, excision repair cross-complementing rodent repair deficiency, complementation group 2 antikoerper, excision repair cross-complementation group 2 antikoerper, Xeroderma pigmentosum D antikoerper, ERCC2 antikoerper, Ercc2 antikoerper, ercc2 antikoerper, Xpd antikoerper

Hintergrund: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. ERCC2 is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. This protein has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COFS2, EM9, MGC102762, MGC126218, MGC126219, TTD, XPD
Protein Interaction Partner: GTF2H2C_2, UBC, FAM96B, CIAO1, rev, CDK7, TP53, MMS19, ERCC3, UVSSA, RAD52, GTF2H1, MNAT1, CCNH, GTF2F1, PIDD1, GTF2H3, GTF2H2, AR, ERCC6, tat, ATF7IP, HERC5, ISG15, TRIM25, RAD51, ERCC5, ERCC2, CDK1,
Protein Size: 760

Molekulargewicht: 87 kDa

Gen-ID: 2068

NCBI Accession: NM_000400, NP_000391

UniProt: P18074

Pathways: DNA Reparatur