ERCC2 Antikörper (C-Term)
-
- Target Alle ERCC2 Antikörper anzeigen
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
-
Bindungsspezifität
- C-Term
-
Reaktivität
- Human, Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser ERCC2 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA
- Spezifität
- ERCC2 Antibody detects endogenous levels of total ERCC2.
- Homologie
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ERCC2, corresponding to a region within C-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product ERCC2 Primärantikörper
-
-
- Applikationshinweise
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
-
- Target
- ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))
- Andere Bezeichnung
- ERCC2 (ERCC2 Produkte)
- Synonyme
- COFS2 antikoerper, EM9 antikoerper, TTD antikoerper, XPD antikoerper, AA407812 antikoerper, AU020867 antikoerper, AW240756 antikoerper, CXPD antikoerper, Ercc-2 antikoerper, MGC89573 antikoerper, CG9433 antikoerper, DhR3 antikoerper, DhXPD antikoerper, DmXPD antikoerper, Dmel\\CG9433 antikoerper, ERCC2 antikoerper, XPD/ERCC2 antikoerper, l(2)SH2 2137 antikoerper, l(2)SH2137 antikoerper, xpd antikoerper, zgc:56365 antikoerper, ERCC excision repair 2, TFIIH core complex helicase subunit antikoerper, excision repair cross-complementing rodent repair deficiency, complementation group 2 antikoerper, excision repair cross-complementation group 2 antikoerper, Xeroderma pigmentosum D antikoerper, ERCC2 antikoerper, Ercc2 antikoerper, ercc2 antikoerper, Xpd antikoerper
- Hintergrund
-
Description: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Gene: ERCC2
- Molekulargewicht
- 87kDa
- Gen-ID
- 2068
- UniProt
- P18074
- Pathways
- DNA Reparatur
-