Caspase 1 Antikörper (Middle Region)
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- Target Alle Caspase 1 (CASP1) Antikörper anzeigen
- Caspase 1 (CASP1)
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Pferd, Kaninchen, Saccharomyces cerevisiae
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Caspase 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- LQTRVLNKEE MEKVKRENAT VMDKTRALID SVIPKGAQAC QICITYICEE
- Homologie
- Horse: 79%, Human: 100%, Rabbit: 79%, Yeast: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against CASP1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CASP1
- Top Product
- Discover our top product CASP1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 383 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Caspase 1 (CASP1)
- Andere Bezeichnung
- CASP1 (CASP1 Produkte)
- Synonyme
- ICE antikoerper, IL1BC antikoerper, P45 antikoerper, Il1bc antikoerper, Ice antikoerper, CASP1 antikoerper, CG5370 antikoerper, DCP-1 antikoerper, DCP1 antikoerper, Dcp1 antikoerper, Dmel\\CG5370 antikoerper, ccp1 antikoerper, dcp-1 antikoerper, dcp1 antikoerper, l(2)01862 antikoerper, l(2)02132 antikoerper, caspase 1 antikoerper, caspase 1, apoptosis-related cysteine peptidase antikoerper, caspase 4, apoptosis-related cysteine peptidase antikoerper, Death caspase-1 antikoerper, caspase-1 antikoerper, caspase antikoerper, caspase recruitment domain-containing protein 16 antikoerper, caspase 4 antikoerper, CASP1 antikoerper, Casp1 antikoerper, CASP4 antikoerper, Dcp-1 antikoerper, Caspase1 antikoerper, LOC5564196 antikoerper, LOC451519 antikoerper
- Hintergrund
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
Alias Symbols: ICE, IL1BC, P45
Protein Interaction Partner: ced-3, ced-4, VAC14, BCL2L1, UBC, XK, PLA2G4B, IL33, IL1B, PARP1, BIRC3, TRAF2, CEBPB, TIRAP, CARD17, CARD16, CARD8, PLA2G4A, CDK11B, NLRP1, ATN1, ATXN3, PYCARD, NLRC4, NOD1, CASP14, RIPK2, PAK1, PARK2, NEDD4, BID, IL18, PSEN2, NFE2L2, AR, BCAP31, MAPT, L
Protein Size: 383 - Molekulargewicht
- 10 kDa
- Gen-ID
- 834
- NCBI Accession
- NM_001223, NP_001214
- UniProt
- P29466
- Pathways
- Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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