CD36 Antikörper

Produktnummer ABIN2689209

Produktdetails anti-CD36 Antikörper

Target: CD36

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD36 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func)

Marke: BD Pharmingen™

Produktmerkmale: The CRF D-2712 antibody reacts with mouse and rat CD36, an 88- kDa glycoprotein member of the class B scavenger receptor family. CD36 is a multifunctional receptor which has a variety of ligands and is expressed on many cell types. Consequently, it is known by several names, including macrophage scavenger receptor, platelet glycoprotein IV, and fatty acid translocase. Cells which express CD36 include platelets, megakaryocytes, monocytes/macrophages, dendritic cells, erythroid precursors, microvascular endothelia, skeletal, cardiac, and smooth muscle cells, adipocytes, and epithelia of retina, breast, and intestine. Therefore, we would not expect to detect CD36 expression by flow cytometry of leukocytes isolated from naive peripheral lymphoid tissues. This multi-ligand receptor functions in the clearance of apoptotic cells and abnormal erythrocytes (in malaria and sickle-cell anemia), the transport of long-chain fatty acids and oxidized low-density lipoproteins, the regulation of angiogenesis by mediating the effects of thrombospondin-1, and the mediation of coronary vasoconstriction. Cross-linking of cell-surface CD36 with plate-bound CRF D-2712 mAb promotes internalization of photoreceptor outer segment fragments by cultured retinal pigment epithelium.

BD Pharmingen™ Purified Mouse Anti-Mouse CD36 - Purified - Clone CRF D-2712 - Isotype Mouse IgA, κ - Reactivity Ms, Rat - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Recombinant mouse CD36

Klon: CRF D

Isotyp: IgA kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD36 Antikörper (ABIN2689209)

Bodart, Febbraio, Demers, McNicoll, Pohankova, Perreault, Sejlitz, Escher, Silverstein, Lamontagne, Ong: "CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart." in: Circulation research, Vol. 90, Issue 8, pp. 844-9, (2002) (PubMed).

Febbraio, Hajjar, Silverstein: "CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism." in: The Journal of clinical investigation, Vol. 108, Issue 6, pp. 785-91, (2001) (PubMed).

Finnemann, Silverstein: "Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium." in: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1289-98, (2001) (PubMed).

Details zu CD36

Target: CD36

Andere Bezeichnung: CD36 (CD36 Produkte)

Synonyme: BDPLT10 antikoerper, CHDS7 antikoerper, FAT antikoerper, GP3B antikoerper, GP4 antikoerper, GPIV antikoerper, PASIV antikoerper, SCARB3 antikoerper, Fat antikoerper, Scarb3 antikoerper, GPIIIB antikoerper, PAS-4 antikoerper, zgc:92513 antikoerper, CD36 molecule antikoerper, CD36 molecule (thrombospondin receptor) antikoerper, CD36 antikoerper, Cd36 antikoerper, cd36 antikoerper

Hintergrund: Synonyms: Scavenger Receptor

Pathways: TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteine